Results: Catalepsy duration was reduced by the non-selective noradrenaline and serotonin reuptake inhibitors imipramine and amitriptyline (21.1% and 22.3% reduction by 20 mg/kg imipramine and amitriptyline, respectively). Catalepsy duration was increased by the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine, and citalopram and by the serotonin receptor antagonist and re...

Due the presence of sibutramine and citalopram in a number of drugs, neurotransmitter reuptake inhibitors. Sibutramine reduces the reuptake of serotonin, norepinephrine, and dopamine; citalopram is an antidepressant drug of the selective serotonin reuptake inhibitor. The thin-layer chromatography-densitometric behavior of some centrally acting serotonin reuptake inhibitors has been studied. The...

It has long been postulated that a deficiency in CNS serotonergic activity is the cause of, or a predisposing factor for, depression. [1] However, the evidence for this association is largely circumstantial and it certainly does not represent an adequate and full model for depression, probably due to there being multiple aetiological factors. [2] Some pharmacological trial data also cast doubt ...

PURPOSE Semen parameters and sperm DNA were evaluated in patients receiving selective serotonin reuptake inhibitors. MATERIALS AND METHODS Semen samples were obtained from 74 fertile, depressed men treated with selective serotonin reuptake inhibitors (group 1) and 44 healthy fertile volunteers who served as a control (group 2). Two semen analyses and physical examinations were completed in al...

data on the effects of serotonin reuptake inhibitors on learning and memory processes are not consistent. in the present study, the effects of citalopram, a very potent and completely selective inhibitor of the serotonin reuptake on spatial discrimination in the t-maze and morris water maze, were assessed in mice and/or rats. animals received different doses of citalopram (1, 2, 4, 8 or 16 mg/k...

Submit Manuscript | http://medcraveonline.com Abbreviations: TCAs: Tricyclic Antidepressants; SSRIs: Selective Serotonin-Reuptake Inhibitors; MAOIs: Monoamine Oxidase Inhibitors; SNRI: Serotonin-Norepinephrine Reuptake Inhibitor; PMDD: Premenstrual Dysphoric Disorder; SAD: Seasonal Affective Disorder; PMS: Premenstrual Syndrome; NE: Norepinephrine; 5-HT: 5-Hydroxytryptamine; DA: Dopamine; CNS: ...

Data on the effects of serotonin reuptake inhibitors on learning and memory processes are not consistent. In the present study, the effects of citalopram, a very potent and completely selective inhibitor of the serotonin reuptake on spatial discrimination in the T-maze and Morris water maze, were assessed in mice and/or rats. Animals received different doses of citalopram (1, 2, 4, 8 or 16 mg/k...