OF all the methods of delaying the absorption of intramuscular penicillin, combination with procaine is at present foremost (Florey 1952). Procaine penicillin is most effective when the particles are smaller than 5 µ and are suspended in a peanut-oil medium with 2% (w/v) aluminium monostearate (Thomas et al. 1948). Emery et al. (1949) showed that in children a serum-penicillin level above...

1. Penicillins F, G, K, and X were all inactivated by human and rabbit serum, but two qualitatively distinct mechanisms were apparently involved. 2. One was a slow inactivation of all four penicillins by a relatively thermostable serum component which was not demonstrably affected by heating for 60 minutes at 56 degrees C. (a) In both human and rabbit serum this general inactivation of penicill...

migraine is one of the common varieties of headache. it involves 4 to 6 percent of men and 13 to 16 percent of women under 30 years in more than 80% of cases. some studies have shown that in 50% of patients serum magnesium level decreases during attacks of headache and using magnesium tablets and intravenous magnesium sulfate is more effective for treatment of migraine attack, than placebo. thi...

autism is a severe neurodevelopmental disorder that characterized by abnormal bilateral social interaction, deficiency in verbal and nonverbal communication, restricted interests and repetitive behaviors .autism caused by the inappropriate immune response which released several cytokines. one of the most important and main causes of autism is a defect in, the formation of the neuronal synaptic ...

Sir, Gaudreau et al. reported a case of group B Streptococcus (GBS) periprosthetic joint infection (PJI) that was treated with oral penicillin (300 mg once daily), but without surgical intervention. After 3 years of suppressive therapy, GBS infection relapsed, and the isolate revealed reduced penicillin susceptibility. A similar case was recently reported by Longtin et al. After 5 years of supp...

Paired specimens of cerebrospinal fluid and serum were taken from 21 patients to estimate penicillin concentrations two to three hours after the last dose of a course of 14-21 daily intramuscular injections of procaine penicillin 0.6 MU. Of 10 patients treated with procaine penicillin alone, eight had no detectable penicillin and two had sub-treponemicidal concentrations (less than 0.018 mg/l) ...

Amoxycillin (alpha-amino-p-hydroxybenzylpenicillin) is a new semi-synthetic penicillin with a broad spectrum of antibacterial activity similar to that of ampicillin. Penicillin-sensitive strains of staphylococci, streptococci, and pneumococci were sensitive to concentrations of 0.1 mug or less of amoxycillin/ml. Strains of Haemophilus influenzae were inhibited by a level of 0.5 mug/ml, and most...

During a study of the serum levels of penicillin necessary for the prophylaxis of rheumatic fever in children (Carron, Maillard, and Pellerat, 1961) we made some observations which could have practical importance in the treatment of syphilis. We observed certain variations in the serum levels after the administration of benzathine penicillin some of which appeared to be rather paradoxical. In g...

hypokalemic disease is a disorder in which the amount of serum’ s potassium declines and the patient faces limbs weakness. in this disease, eye muscle and respiratory muscles rarely become involved and death may follow due to respiratory paralysis and heart conducting disturbances. since this disease is treatable and progressive weakness can be prevented, therefore in the study conducted we att...

Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by inhibiting the excretion of organic acids from CSF. We have studied this phenomenon with various penicillin and cephalosporin derivatives. Penicillin concentrations were determined in rabbits under steady-state conditions before and after intravenous probenecid administration. With both low-dose and high-dose ...