Overexpression of ABCB1 (MDR1) P-glycoprotein, a multidrug efflux pump, is one mechanism by which tumor cells may develop multidrug resistance (MDR), preventing the successful chemotherapeutic treatment of cancer. Sesquiterpenes from Celastraceae family are natural compounds shown previously to reverse MDR in several human cancer cell lines and Leishmania strains. However, their molecular mecha...

Electron microscopy of the cells of the thermogenic appendix of Sauromatum guttatum has revealed a fusion event between pocket-like structures of the rough endoplasmic reticulum (rER) and the plasma membrane. As a result of the fusion event, many regions of the plasma membrane have paired unit membranes (four leaflets instead of two). The fusion allows the transfer of osmiophilic material from ...

pycnocycla spinosa aerial parts were collected weekly during four-month growth. hydrodistillation and gas chromatography coupled with mass spectroscopy techniques were used for essential oil and sesquiterpenes investigation. thirty-four components were identified, of which the characteristic sesquiterpenes were a -copaene, caryophyllene, a -humulene, b-ionene, d-cadinene, a -calacorene, caryoph...

This study investigates the secondary organic aerosol formation during ozonolysis of one most important sesquiterpenes, α-humulene. Sesquiterpenes are emitted by vegetation and can be biogenic precursors fine particles.

the chemical composition of essential oils isolated from the leaves of cosmos bipinnatus and its antibacterial activity were analyzed by gc-ms and microbroth dilution assay respectively. the essential oil extracted from this plant was predominantly composed of monoterpenes (69.62%) and sesquiterpenes (22.73%). the antibacterial assay showed that the oil had significant inhibitory effects agains...

In addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A-D (1-4), a new chamigrane derivative, okamurene E (5), and a new C₁₂-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compounds were determined through detailed spectroscopic analyses. Of these, okamurenes A and B (1 and 2) are the first examples of...

The intestinal permeability of eight sesquiterpenes which are active constituents of some traditional Chinese medicines, were studied by using the Caco-2 cell monolayer; they include tanacetin, artesin, magnolialide, crossostephin, atractylon, isocalamenediol (ICL), bisabolangelone (BSE) and (3 R)-des- O-methyllasiodiplodin (DML). The bidirectional permeability of the eight sesquiterpenes was s...

The volatile oil obtained by hydrodistillation of the petals of Rosa damascena Mill. (Rosaceae) was analyzed by gas chromatography and gas chromatography/mass spectrometry (GC/MS). The yield of the oil was 0.12 % (v/w). Fifty compounds representing 99.06 % of the oil were characterized. The volatile oil was found rich in sesquiterpenes and aliphatic components, consisting of two monoterpenic es...

A new sesquiterpene evoninate alkaloid (1), and two sesquiterpenes (2, 3) with a dihydro-beta-agarofuran skeleton, along with three known sesquiterpenes (4-6), were isolated from the seeds of Euonymus europaeus. Their structures were elucidated by high resolution mass analysis, and one- and two-dimensional (1D and 2D) NMR spectroscopy, including homonuclear and heteronuclear correlation [correl...