Mexiletine as the first choice drug in myotonia treatment is a chiral sodium channel blocker clinically used in its racemic form. The phenolic structure of this drug, prompted us to design its novel calix[4]arene-based cluster in a chalice-shaped structure. Therefore, the present study reports the synthesis and in-vitro anti-myotonic activity of the chalice-shaped cluster of mexiletine...

This paper presents an experimental research on the distribution of local friction factor, fb, and global friction factor, f, over the cross-section of a channel with V-shaped bottom, which typically occurs in sewers and culverts. Several series of experiments were conducted for measuring velocity and boundary shear stress. It is found that, Darcy-Weisbach, f, is more sensitive than other resis...

For applications in high-density and high-speed optical interconnections, we propose to utilize polymer parallel optical waveguides (PPOWs) with so-called W-shaped refractive index profile in the core area. A W-shaped index profile is composed of a parabolic index distribution surrounded by a narrow index valley, followed by a cladding with a uniform refractive index. We expect that W-shaped in...

The appearance of detergent-solubilized voltage-regulated sodium channel protein was recently characterized by this laboratory. Negative-staining revealed rod-shaped particles measuring 40 X 170 A. Further studies have suggested that the actual configuration of this protein may be quite different from the rod-shaped structures. Freeze-fracture and freeze-etch images of the protein in reconstitu...

The results of an experimental investigation of kerbside bridge deck drainage units are presented. The conveyance capacity, resistance coefficients and sediment transporting efficiencies of different types of drainage unit used in shallow bridge drainage decks are examined over a range of bed gradients likely to be encountered in practice. The use of a V-shaped cross section is shown to be part...