Endothelial cells are constantly exposed to fluid shear stresses that regulate vascular morphogenesis, homeostasis, and disease. The mechanical responses of endothelial cells to relatively high shear flow such as that characteristic of arterial circulation has been extensively studied. Much less is known about the responses of endothelial cells to slow shear flow such as that characteristic of ...

This study investigated bending, buckling, and free vibration responses of hyperbolic shear deformable functionally graded (FG) higher order beams. The material properties of FG beams are varied through thickness according to power law distribution; here, the FG beam was made of aluminium/alumina, and the hyperbolic shear deformation theory was used to evaluate the effect of shear deformation i...

Recent methods have revealed that cells on planar substrates exert both shear (in-plane) and normal (out-of-plane) tractions against the extracellular matrix (ECM). However, the location and origin of the normal tractions with respect to the adhesive and cytoskeletal elements of cells have not been elucidated. We developed a high-spatiotemporal-resolution, multidimensional (2.5D) traction force...

The aged-rejuvenation-glue-liquid (ARGL) shear band model has been proposed for metallic glasses (Acta Mater. 54 (2006) 4293), based on small-scale molecular dynamics simulations up to 20,000 atoms and thermomechanical analysis. The model predicts the existence of a critical lengthscale 10 nm, above which melting could occur in shear-alienated glass. Large-scale molecular dynamics simulations w...

We describe a first-principles-based strategy to predict the macroscopic toughness of a c-Ni(Al)/a-Al2O3 interface. Density functional theory calculations are used to ascertain energy changes upon displacing the two materials adjacent to the interface, with relaxation conducted over all atoms located within adjoining rows. Traction/displacement curves are obtained from derivatives of the energy...

A conclusive demonstration has been provided that the nature of the shearthinning, that affects both film thickness and traction in EHL contacts, follows the ordinary power-law rule that has been described by many empirical models of which Carreau is but one example. This was accomplished by accurate measurements in viscometers of the shear response of a PAO that possesses a very low critical s...

This paper presents an analytical refined beam model taking into account the axial, shear and transverse normal stress distributions. Based on equilibrium equations in local form iterative procedure for solution of bipotential equation, differential axial motion are derived. From a mathematical point view formal structure obtained is identical to Timoshenko but with increased accuracy. achieved...

Cropping is a cutting process whereby opposing aligned blades create a shearing failure by exerting opposing forces normal to the surfaces of a metal sheet or plate. Building on recent efforts to quantify cropping, this paper formulates a plane strain elastic–plastic model of a plate subject to shearing action by opposing rigid platens. Shear failure at the local level is modeled by a cohesive ...