The postnatal development of the mouse is characterized by a stress hypo-responsive period (SHRP), where basal corticosterone levels are low and responsiveness to mild stressors is reduced. Maternal separation is able to disrupt the SHRP and is widely used to model early trauma. In this study we aimed at identifying of brain systems involved in acute and possible long-term effects of maternal s...

As rapid brain development occurs during the neonatal period, environmental manipulation during this period may have a significant impact on sleep and memory functions. Moreover, rapid eye movement (REM) sleep plays an important role in integrating new information with the previously stored emotional experience. Hence, the impact of early maternal separation and isolation stress (MS) during the...

The main characteristic of the postnatal development of the stress system in the rat is the so-called stress hypo-responsive period (SHRP). Lasting from postnatal day (pnd) 4 to pnd 14, this period is characterized by very low basal corticosterone levels and an inability of mild stressors to induce an enhanced ACTH and corticosterone release. During the last years, the mouse has become a genera...

The effectiveness of weight ratio mineral filler to effective bitumen in the fatigue performance asphalt mixture with integral granules was investigated based on experiments mastic (mixture and passed through sieve grade 200). included a dynamic shear rheometer, elastic recovery, linear amplitude sweep tests other mixture, such as indirect tensile resilient modulus test for assessing medium tem...

The question of whether early life exposure to general anesthesia induces neurodevelopmental abnormalities in humans, similar to what has been demonstrated in animals from rodents to rhesus monkeys, is complex and of significant clinical concern, given that more than 1 in 4 children undergo procedures requiring anesthesia in their first year of life [1]. Important roadblocks to understanding th...

The authors present a simple elastostatic approach to estimate a suitable subgrade modulus from falling weight deflectometer (FWD) data. An effective surface modulus is defined on the basis of Boussinesq-Newmark equations. Deviations between the model assumptions and actual in situ conditions are reflected in the effective surface modulus variation with radius. The variation indicates which sen...

Diffusion-reaction models derived within the frame of continuum thermodynamics irreversible processes for reacting mixtures enjoy a number advantages over purely phenomenological models. This paper explores potential and challenges this approach by means particular model spurt oxidation in bitumen. Film ageing experiments are simulated considering different bitumen compositions terms SARA fract...