نتایج جستجو برای: sicam 1

تعداد نتایج: 2752593  

Journal: :Clinical chemistry 2002
Thomas Krauss Günter Emons Walther Kuhn Hellmut G Augustin

BACKGROUND The present study was aimed at determining whether routine prenatal measurements of circulating soluble intercellular adhesion molecule (sICAM-1; CD54) and soluble vascular cell adhesion molecule (sVCAM-1; CD106) in midgestation have predictive value for the identification of pregnant women destined to develop preeclampsia or other complications of pregnancy during late gestation. ...

2001
Yong Song Gho Phillia N. Kim Hao-Chuan Li Michael Elkin Hynda K. Kleinman

Because serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) are elevated in cancer and sICAM-1 is angiogenic, we tested the ability of sICAM-1 to promote tumor growth. Our preliminary experiments showed that exogenous sICAM-1 significantly stimulated the growth of human tumors in vivo. Human fibrosarcoma transfectants, which express ICAM-1, produce ICAM-1 on the cell surface and...

Journal: :Polskie Archiwum Medycyny Wewnetrznej 2009
Grazyna Biesiada Jacek Czepiel Iwona Sobczyk-Krupiarz Dominika Salamon Aleksander Garlicki Tomasz Mach

INTRODUCTION Lyme disease is a multi-organ animal-borne disease caused by the spirochete Borrelia burgdorferi (Bb). OBJECTIVES As the pathogenesis of Lyme borreliosis is not fully understood, the study has been designed to examine levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) in serum and the cerebrospinal fluid (CSF) of ...

Journal: :Cancer research 2001
Y S Gho P N Kim H C Li M Elkin H K Kleinman

Because serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) are elevated in cancer and sICAM-1 is angiogenic, we tested the ability of sICAM-1 to promote tumor growth. Our preliminary experiments showed that exogenous sICAM-1 significantly stimulated the growth of human tumors in vivo. Human fibrosarcoma transfectants, which express ICAM-1, produce ICAM-1 on the cell surface and...

2011
Michael P Mendez Yeni K Monroy Ming Du Angela M Preston Leslie Tolle Yujing Lin Kelli L VanDussen Linda C Samuelson Theodore J Standiford Jeffery L Curtis James M Beck Paul J Christensen Robert Paine

BACKGROUND A sizeable body of data demonstrates that membrane ICAM-1 (mICAM-1) plays a significant role in host defense in a site-specific fashion. On the pulmonary vascular endothelium, mICAM-1 is necessary for normal leukocyte recruitment during acute inflammation. On alveolar epithelial cells (AECs), we have shown previously that the presence of normal mICAM-1 is essential for optimal alveol...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Paul J Mills Barbara Parker Vicky Jones Karen A Adler Christy J Perez Sherella Johnson Mairav Cohen-Zion Matthew Marler Georgia R Sadler Joel E Dimsdale Sonia Ancoli-Israel

PURPOSE The circulating soluble form of intercellular adhesion molecule-1 (sICAM-1) and vascular endothelial growth factor (VEGF) are elevated in women with breast cancer and associated with tumor progression and poor prognosis. This study examined the effects of anthracycline-based chemotherapy on plasma sICAM-1 and VEGF, as well as soluble P-selectin, von Willebrand factor, and interleukin-6 ...

Journal: :Blood 1994
I Christiansen C Gidlöf A C Wallgren B Simonsson T H Tötterman

The serum levels of soluble intercellular adhesion molecule 1 (ICAM-1) were significantly elevated (P < .001) in patients with chronic B-lymphocytic leukemia (B-CLL, n = 113) compared with healthy controls (n = 31). sICAM-1 levels in B-CLL were positively correlated to the tumor mass as reflected by the modified Rai and the Binet staging systems, lymphocyte counts, and isolated spleno/hepatomeg...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2006
Michael P Mendez Susan B Morris Steven Wilcoxen Elizabeth Greeson Bethany Moore Robert Paine

Intercellular adhesion molecule-1 (ICAM-1; CD54) is an adhesion molecule constitutively expressed in abundance on the cell surface of type I alveolar epithelial cells (AEC) in the normal lung and is a critical participant in pulmonary innate immunity. At many sites, ICAM-1 is shed from the cell surface as a soluble molecule (sICAM-1). Limited information is available regarding the presence, sou...

Journal: :Circulation 2000
C A Labarrere D R Nelson S J Miller J M Nieto J A Conner D E Pitts P C Kirlin H G Halbrook

BACKGROUND Adhesion molecules on arterial endothelium have been implicated in spontaneous atherosclerosis and transplant coronary artery disease (CAD). We studied whether elevated serum-soluble intercellular adhesion molecule-1 (sICAM-1) during the immediate posttransplant period was a risk factor for CAD, posttransplant ischemic events, or cardiac graft failure. METHODS AND RESULTS We initia...

Journal: :Annals of clinical and laboratory science 2002
Sirzat Cogalgil Seyithan Taysi

Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), ceruloplasmin (Cp), and transferrin (Tf) were measured in patients with rheumatoid arthritis (RA) and the correlations of these parameters with disease activity were investigated. Serum sICAM- 1 levels were determined by a sandwich enzyme-linked immunosorbant assay (ELISA) in serums from 42 patients with RA and 30 healthy cont...

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