Purpose: To develop a nanosuspension drug delivery system to enhance the dissolution rate of Silybum marianum seeds extract.
 Methods: Central composite design was used study effect input variables (stabilizer plant extract ratio, antisolvent solvent stirring time) on dependent (mean particle size, polydispersity index (PDI) and zeta potential). The optimized formulation characterized by S...

The effect of new synthetic pyrazinecarboxamide derivatives as potential elicitors of flavonolignan and flavonoid production in Silybum marianum and Ononis arvensis cultures in vitro was investigated. Both tested elicitors increased the production of flavonolignans in S. marianum callus and suspension cultures and flavonoids in O. arvensis callus and suspension cultures. Compound I, 5-(2-hydrox...

Deve dikeni (Silybum marianum) tohumuna çözücü ile ekstraksiyon yöntemi uygulanarak %7,3 verimle silimarin tozu elde edilmiştir. Ekstrakte tozun %57,8 içerdiği bulunmuştur. Silimarin içeriği dikkate alınarak silybum marianum tohumunun %4,21 olarak Ekstrakt ve orjinal silimarin, Fourier dönüşümlü kızıl ötesi spektroskopisi (FTIR), Optik Mikroskop, X-ışını kırınımı (XRD) taramalı elektron mikrosk...

background and objectives: milk thistle (silybum marianum), a medicinal plant of the asteraceae family that have been used long time ago, in the treatment of liver disease. sowing date of this plant has not been determined, therefore, this study was necessary. this plant was identified as a weed, this plant is identified as a weed, while silymarin in the seeds are used in the anti-hepatitis and...

The paper presents the antioxidant activity evaluation of Silybum marianum L. extract in comparison with the commercial silymarin standard solution (2 mg/mL) and the time-dependent antioxidant capacity by calculating the free radical 2,2-diphenyl-1-pycryl-hydrazyl (DPPH) reaction rate in the presence of these biosystems. The best result was obtained in the case of S. marianum L. extract, with a...

Early growth water stress reduces the extract and fresh oil of Silybum marianum L. (S. marianum) shoots. Two experiments were conducted to reduce effects early drought. Treatments in first experiment organic seed cover fillers at three levels (control, vermicompost, peat moss), hydrogel seven 2, 4, 6 g hydrogelF1 per kg OSC, hydrogelA200 cover), deficit (100, 50, 25% field capacity), second exp...

In this study, the process of separating and analyzing oils from some plant seeds such as Washingtonia tree Silybum marianum(kulgan) Soxhlat apparatus was used in extraction process, where performed using organic solvents (Hexane Petroleum ether). Then appreciation percentage oil these plants. It found that marianum contain a higher than tree. Then, active functional groups were identified (FT-...