Medial-frontal negativity occurring ∼200-300 ms post-stimulus in response to motivationally salient stimuli, usually referred to as feedback-related negativity (FRN), appears to be at least partly modulated by dopaminergic-based reward prediction error (RPE) signaling. Previous research (e.g., Smillie et al., 2011) has shown that higher scores on a putatively dopaminergic-based personality trai...

Simulating variations pre-Si can be very time consuming. Running enough Monte Carlo simulations at the five process corners takes a non-trivial amount of time, particularly for larger designs. This paper describes a method for decreasing time for simulating process variations by reducing the number of required simulations. Through noise-analysis and Monte Carlo simulations conducted in commerci...

Despite promising reports of the use of omalizumab as add-on therapy in patients with systemic mastocytosis and recurrent anaphylaxis during specific venom immunotherapy (VIT), unpredicted adverse effects may lead to therapy failure. We present the case of a patient with systemic mastocytosis and Hymenoptera venom allergy who was administered omalizumab as add-on therapy to improve VIT tolerabi...

The expression measurements of thousands of genes are correlated with the proportions of tumor epithelial cell (PTEC) in clinical samples. Thus, for a tumor diagnostic or prognostic signature based on a summarization of expression levels of the signature genes, the risk score for a patient may dependent on the tumor tissues sampled from different tumor sites with diverse PTEC for the same patie...

The predictive coding model of perception proposes that neuronal responses are modulated by the amount of sensory input that the internal prediction cannot account for (i.e., prediction error). However, there is little consensus on what constitutes nonpredicted stimuli. Conceptually, whereas mispredicted stimuli may induce both prediction error generated by prediction that is not perceived and ...

Goal-oriented, rational threat agents attack a complex ICT infrastructure by composing elementary attacks against distinct components into an attack chain or attack plan. To compute statistics on the success probabilities of these plans, we have designed and implemented Haruspex, a tool that implements a Monte Carlo method by simulating the agent plans. A proper set of Haruspex experiments retu...

Visual cues open a unique window to the understanding of Parkinson's disease (PD). These cues can temporarily but dramatically improve PD motor symptoms. Although details are unclear, cues are believed to suppress pathological basal ganglia (BG) activity through activation of corticostriatal pathways. In this study, we investigated human BG neurophysiology under different cued conditions. We ev...

BACKGROUND Unpredicted pregnancy is an evolution of the concepts undesired and unplanned pregnancy. It is more common among vulnerable strata of our society and related to lack of education. AIM To explore the prevalence and social concomitants of unpredicted pregnancy among young women. MATERIAL AND METHODS Analysis of the databases of the Sixth National Youth Survey carried out by the Ins...