Diabetes Mellitus is a chronic metabolic disorder arises due to absolute lack of insulin secretion (T1DM) or its action or both (T2DM). Alterations in glucose metabolism in DM are frequently accompanied by impairment in the activities of enzymes that regulate carbohydrate metabolism. Liver is a vital organ that acts as primary site of endogenous glucose production through gluconeogenesis or gly...

Raphanus sativus, Brassicaceae, Sinapic Acid Esters, Phenylpropanoids, High Performance Liquid Chromatography Five sinapic acid esters were isolated from cotyledons of Raphanus sativus and have been iden­ tified with the aid of electron impact (El)-, field desorption (FD)-mass spectrometry and NMR spectroscopy: 6,3'-disinapoylsucrose, sinapoylcholine (sinapine), 6 -sinapoylglucoraphenine, 1 -si...

The mechanism and kinetics underlying reactions between the naturally-occurring antioxidant sinapic acid (SA) and the very damaging ·NO2 and ·OH were investigated through the density functional theory (DFT). Two most possible reaction mechanisms were studied: hydrogen atom transfer (HAT) and radical adduct formation (RAF). Different reaction channels of neutral and anionic sinapic acid (SA-) sc...

The influence of addition 2,4,6,8, and 10 microM of benzoic and cinnamic acids and selected phenolic acids (salicylic, p-hydroxybenzoic, gentisic, protocatechuic, vanillic, syringic, o-coumaric, p-coumaric, caffeic, ferulic, sinapic) on the activity of pancreatic lipase was examined in vitro. The strongest inhibition activities were observed with caffeic, ferulic and benzoic acid, while sinapic...

The aim of the present study was to evaluate the free radical scavenging and antioxidants in DMBA induced hamster buccal pouch carcinogenesis in golden Syrian hamsters. A total of 32 animals were divided into 4 groups of 8 animals each. Group I served as control and received normal saline only. Group II animals were painted with 0.5% DMBA with liquid paraffin three times a week for 16 weeks on ...

Experimental evidence for the presence in mustard seedlings of an esterase that catalyzes the hydrolysis of sinapine into sinapic acid and choline has been presented previously (12). It was felt that further studies on this enzyme might be of some general biochemical interest. A preparation of sinapine esterase purified 20fold has been obtained from white mustard seedlings (Brassica hirta Moenc...

Recent research has significantly advanced our understanding of the phenylpropanoid pathway but has left in doubt the pathway by which sinapic acid is synthesized in plants. The reduced epidermal fluorescence1 (ref1) mutant of Arabidopsis thaliana accumulates only 10 to 30% of the sinapate esters found in wild-type plants. Positional cloning of the REF1 gene revealed that it encodes an aldehyde...

Sinapic acid, 3,5-dimethoxyl-4-hydroxycinnamic belonging to the class of hydroxycinnamic acids, shows antioxidant, anti-inflammatory, anticancer, hepatoprotective, cardioprotective, renoprotective, neuroprotective, antidiabetic, anxiolytic, and antibacterial activity. The aim this work was incorporate sinapic acid into solid lipid nanoparticles in order improve its bioavailability. SLNs were pr...

Cinnamic acid and its hydroxylated derivatives (p-coumaric, caffeic, ferulic and sinapic acids) are known allelochemicals that affect the seed germination and root growth of many plant species. Recent studies have indicated that the reduction of root growth by these allelochemicals is associated with premature cell wall lignification. We hypothesized that an influx of these compounds into the p...

Purple carrots accumulate abundant cyanidin-based anthocyanins in taproots. UDP-glucose: sinapic acid glucosyltransferase (USAGT) can transfer the glucose moiety to the carboxyl group of sinapic acid thereby forming the ester bond between the carboxyl-C and the C1 of glucose (1-O-sinapoylglucose). 1-O-sinapoylglucose can serve as an acyl donor in acylation of anthocyanins and generate cyanidin ...