Diabetic retinopathy is characterized by progressive vision loss and the advancement of retinal micoraneurysms, edema and angiogenesis. Unfortunately, managing glycemia or targeting vascular complications with anti-vascular endothelial growth factor agents has shown only limited efficacy in treating the deterioration of vision in diabetic retinopathy. In light of growing evidence that mitochond...

We recently analyzed a series of H5N1 viruses isolated from healthy ducks in southern China since 1999 and found that these viruses had progressively acquired the ability to replicate and cause disease in mice. In the present study, we explored the genetic basis of this change in host range by comparing two of the viruses that are genetically similar but differ in their ability to infect mice a...

Single-Nanowire Surface-Enhanced Raman Scattering Paritosh Mohanty,† Ilsun Yoon,† Taejoon Kang,† Kwanyong Seo,† Kumar S. K. Varadwaj,† Wonjun Choi,‡ Q-Han Park,‡ Jae Pyung Ahn,§ Yung Doug Suh,| Hyotcherl Ihee,† and Bongsoo Kim*,† Department of Chemistry, KAIST, Daejeon 305-701, Korea, Department of Physics, Korea UniVersity, Seoul 136-701, Korea, Nano-Material Research Center, KIST, Seoul 136-7...

in Alexandrite Single Crystal * T. H. Yeom, S. H. Choh , K. S. Hong , H. Y. Yeom, Y. H. Park , and Y. M. Yu a Department of Physics, Chongju University, Chongju 360-764, Korea b Department of Physics, Korea University, Seoul 136-701, Korea c Korea Basic Science Institute, Seoul Branch, Korea University Campus, Seoul 136-701, Korea d Department of Physics, Dankook University, Cheonan 330-180, Ko...

Activating mutations of FMS-like tyrosine kinase 3 (FLT3) are present in approximately 30% of patients with de novo acute myeloid leukemia (AML) and are associated with lower cure rates from standard chemotherapy-based treatment. Targeting the mutation by inhibiting the tyrosine kinase activity of FLT3 is cytotoxic to cell lines and primary AML cells harboring FLT3 mutations. Successful FLT3 in...

Fertilizer management is essential for achieving sustainable agriculture and protecting the environment. To evaluate the effect of Nitroxin bio-fertilizer application on quantitative and qualitative traits of corn hybrids a farm research was arranged via split plot experiment based on the randomized complete block design with four replications in 2013. Main plots were Included: use of the chemi...

BACKGROUND: Phyllodes tumors are biphasic fibroepithelial neoplasms of the breast. While the surgical management of these relatively uncommon tumors has been addressed in the literature, few reports have commented on the surgical approach to tumors greater than ten centimeters in diameter – the giant phyllodes tumor. CASE REPORT: We report a case of a 45-year-old woman who presented with a larg...

NCX-701 is a nitric oxide (NO)-releasing acetaminophen (APAP) derivative. In the present study we demonstrated that NCX-701 is as effective as APAP in controlling body temperature in a rat model of endotoxin-induced fever. Liver toxicity is a major complication of APAP overdosing. To investigate whether NCX-701 is hepatotoxic, BALB/C mice were injected with 100 - 500 mg kg(-1) APAP or NCX-701 a...