Objective(s): Asthma, the most frequent chronic respiratory disease, results from a complex interaction between multiple genes and environmental factors. To date, more than 100 candidate genes and single nucleotide polymorphisms (SNPs) have been reported to be associated with asthma. One of the discovered genes related to asthma is ADAM33. However, the relationship between ADAM33 gene polymorph...

background: despite extensive progress in ivf techniques, one of the most difficult problems is the variability in the response to controlled ovarian hyperstimulation (coh). recent studies show the effects of individual genetic variability on coh outcome. objective: to evaluate the correlation between lhβ g1502a polymorphisms in exon 3 of the lh gene and ovarian response to coh. materials and m...

background: half of the cases of vision loss in people under 60 years of age have been attributed to age-related macular degeneration (amd). this is a multifactorial disease with late onset. it has been demonstrated that many different genetic loci are implicated in the risk of developing amd in different populations. in the current study, we investigated the association of high-temperature ‎re...

conclusions although previous studies have shown that a-g transition mutations in 23 srrna gene (domain v) are the main reason for the occurrence of high level macrolides resistance in b. pertussis, however, the mentioned single nucleotide polymorphisms (snps) have not been detected in our resistant strain. this is the first report of high level macrolide resistant b. pertussis, without snps in...

objective(s): coronary artery disease (cad) is the leading cause of death in both male and female worldwide. the main cause of cad is the atherosclerosis of coronary arteries, which is, mostly caused by genetic alteration. 50% of such cases occur in mitotic cells where single-strand breaks occur spontaneously or due to ionizing radiation. x-ray repair cross-complementing protein 1 (xrcc1) as a ...

Recent pre-clinical and clinical studies have revealed the C-reactive protein gene (CRP) is related to the degree of acute rise in plasma C-reactive protein (CRP) levels. Moreover, single nucleotide polymorphisms (SNPs) in the CRP gene could associate with increased risk of cancer, atherosclerosis, diabetes mellitus, bowel disease, rheumatoid arthritis, psoriasis, obstructive pulmonary disease,...

Single Nucleotide Polymorphisms (SNPs) are the most common source of genetic variations. There has been enormous research in the area of Biocomputing and Bioinformatics on identification and analysis of SNPs. A large number of methods have been developed for their identification ever since the importance of SNPs in understanding of diseases emerged with the completion of Human Genome Project. T...

the immunoreceptor programmed cell death-1 (pd-1) is a cell surface molecule that is reported to play an important role in the regulation of peripheral tolerance. it has been shown that pd-1 gene is associated with susceptibility to the autoimmune disease systemic lupus erythematosus (sle) in humans. however, there are no reports on the association between this gene and multiple sclerosis (ms)....