With recent advances in high-throughput single nucleotide polymorphism (SNP) typing technologies, genome-wide association studies have become a realistic approach to identify the causative genes that are responsible for common diseases of complex genetic traits. In this strategy, a trade-off between the increased genome coverage and a chance of finding SNPs incidentally showing a large statisti...

The plate loop count as described in Standard Methods for the Examination of Dairy Products, 13th Edition, was investigated as a simplified technique for determining total viable counts in single strength orange juice. This pro cedure requires the use of standardized loops (0.01 and 0.001) for making serial dilutions in stead of pipets and dilution bottles. Data have been presented to show ther...

We present a method for computing sample size for cluster-randomized studies involving a large number of clusters with relatively small numbers of observations within each cluster. For multivariate survival data, only the marginal bivariate distribution is assumed to be known. The validity of this assumption is also discussed.

BACKGROUND Because common diseases are caused by complex interactions among many genetic variants along with environmental risk factors, very large sample sizes are usually needed to detect such effects in case-control studies. Nevertheless, many genetic variants act in well defined biologic systems or metabolic pathways. Therefore, a reasonable first step may be to detect the effect of a group...

In this vignette, we demonstrated the application of RnaSeqSampleSize as an sample size estimation tool for RNA-seq data. A user friendly web interface is also provided at http: //cqs.mc.vanderbilt.edu/shiny/RnaSeqSampleSize/ for researchers not familar with R. RnaSeqSampleSize package provides the following features: • Estimation of sample size or power by single read count and dispersion; • E...

A simple extension to ray tracing is presented that creates visually plausible “soft” shadows with little extra computation. Although these soft shadows are approximate, they are robust and have penumbra widths that behave in a believable way, including accurate placement of singularities where penumbra width is zero. The method has continuous behavior in space and time, so it is appropriate fo...