Endothelin-1 (ET-1), a potent vasoactive peptide, plays an important role in the pathogenesis of liver disease and portal hypertension. Two major endothelin receptors (ET-A and ET-B) mediate biological effects, largely on the basis of their known downstream signaling pathways. We hypothesized that the different receptors are likely to mediate divergent effects in portal hypertensive mice. Liver...

• In several investigations in the past, Wetterer and Pieper connected a sinusoidal piston pump to the arterial system of intact anesthetized dogs in order to produce slow oscillations of the mean arterial pressure upon which the arterial pressure pulsation was superimposed. Simultaneous measurements of various parameters permitted the calculation of the elasticity coefficient of the arterial r...

A study is presented of the post-buckling behavior and imperfection-sensitivity of complete spherical shells subject to uniform external pressure. The study builds on and extends the major contribution to spherical shell buckling by W.T. Koiter in the 1960’s. Numerical results are presented for the axisymmetric large deflection behavior of perfect spheres followed by an extensive analysis of th...

Obstruction of the hepatic venous outflow tract results in increased hepatic sinusoidal pressure and portal hypertension. In the early stages, portal venous perfusion of the liver is decreased, which may result in portal venous thrombosis. 2 The ensuing venous stasis and congestion lead to hypoxic damage to adjacent hepatic parenchymal cells. Furthermore, the ischemic injury to the sinusoidal l...

The buckling behavior of rod strings in wellbore is one of the key issues in petroleum engineering. The slender rod strings in vertical wellbore were selected as research objects. Based on the energy method, the critical load formulas of sinusoidal and helical buckling were derived for the string with the bottom of the wellbore pressure. According to the sinusoidal and helical buckling’s geomet...

We propose a new transient model which naturally extends the sinusoidal model to nonstationary phenomena. An integrated online-offline segmentation approach is developed, followed by an explicitly time-variant sinusoidal model.