The lungs may be involved in patients with histiocytosis X as part of the generalised disease, but histiocytosis X confined to the lungs without extrapulmonary involvement is rare. This report describes two cases of primary pulmonary histiocytosis arising in patients with Hodgkin's disease. It is impossible to state with certainty whether the pulmonary histiocytosis arose as a response to the d...

Langerhans cell histiocytosis (LCH) is a rare neoplastic lesion characterized by accumulation of cells having major phenotypic features of skin Langerhans cells. It usually affects young children but rare cases were also reported in adults. The clinical spectrum of LCH includes Letterer–Siwe disease, Hand–Schüller–Christian disease, eosinophilic granuloma, Langerhans cell sarcoma as well as int...

In Letterer-Siwe disease, oral and dental pathology is an unusual occurrence. Failure to consider this condition in patients with gingival inflammation, necrosis, or premature eruption of teeth may lead to delay in diagnosis. We present two cases with these features. Case Reports Case 1. This boy was aged 4 months when he developed sore, swollen gums with white necrotic areas. He was treated fo...

Eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease are three disorders characterized by proliferating histiocytes. Collectively, they are called histiocytosis X. Histiocytosis X often presents with lytic calvarial lesions [1]. Hypothalamic involvement is the most common intracranial manifestation [2]. Solitary histiocytosis X within the cerebral hemispheres, alth...

A case of Langerhans Cell Histiocytosis (LCH) is reported in 1½ years old boy. He had seborrhoeic dermatitis like condition of scalp, papular lesions with purpura typical of Letterer-Siwe disease associated with constitutional symptoms, hepatosplenomegaly, jaundice, anaemia and thrombocytopenia. Peripheral blood film and bone marrow examination showed presence of LCH cells.

Langerhans cell histiocytosis (LCH) and malignancy occurring in the same individual is unusual and has generally been the subject of isolated case reports. LCH is a rare condition in adults. Its cause is uncertain but, with the recent demonstration of clonality and its association with malignant disease, there has been a renewal of interest. We report a singular case of Letterer-Siwe disease as...