objective(s): pregabalin (pgb) is a new antiepileptic drug that has received fda approval for patient who suffers from central neuropathic pain, partial seizures, generalized anxiety disorder, fibromyalgia and sleep disorders. this study was undertaken to evaluate the possible adverse effects of pgb on the muscular system of mice. materials and methods: to evaluate the effect of pgb on skeletal...

Usually mathematicians use Hodgkin-Huxley model or FitzHug-Nagumo model to simulate action potentials of skeletal muscle fibers. These models are electrically excitable, but skeletal muscle fibers are stimulated chemically. To investigate skeletal muscle fibers we use a model with six ordinary differential equations. This dynamical system is sensitive to initial value of some variables so it is...

Objective(s): Pregabalin (PGB) is a new antiepileptic drug that has received FDA approval for patient who suffers from central neuropathic pain, partial seizures, generalized anxiety disorder, fibromyalgia and sleep disorders. This study was undertaken to evaluate the possible adverse effects of PGB on the muscular system of mice. Materials and Methods: To evaluate the effect of PGB on skeletal...

Skeletal muscle comprises the major organ system in our bodies and is effector tissue for fundamental processes, such as movement, breathing glucose homeostasis. However, regeneration can be insufficient to repair injuries or become exhausted by ongoing fiber damage that occurs muscular dystrophy. Cell therapy provide a source of myogenic stem cells repopulate lost fibers an attractive option t...

A recommendation of: Audrey Quéméner, Frédéric Dessauge, Marie-Hélène Perruchot, Nathalie Le Floc’h, Isabelle Louveau The impact of housing conditions on porcine mesenchymal stromal/stem cell populations differ between adipose tissue and skeletal muscle https://doi.org/10.1101/2021.06.08.447546