background autoimmune hepatitis (aih) is a form of chronic hepatitis with unclear causative factors and is characterized by immunological and auto-immunological manifestations. several extrahepatic manifestations, such as other autoimmune disorders, are associated with aih. aih with dermatological conditions as the initial manifestation is rare. we report the case of aih in which erythema nodos...

Skin metastasis is a rare manifestation of internal malignancy. Presence of cutaneous metastasis can be seen in 6.4% of all malignancy at some point in time. Cutaneous metastases as a presentation of upper gastrointestinal malignancy is far less common (<1%). Here we present a case of poorly differentiated adenocarcinoma of the stomach that presented with extensive metastases of skin, liver and...

lipoid proteinosis (lp) is a rare autosomal recessive disease characterized by the deposition of an amorphous hyaline material in the skin, mucosa and viscera. the classic manifestation is onset in infancy with a hoarse cry due to laryngeal infiltration. skin and mucous changes develope, and the disease follows a slowly progressive course. in this case report, a 49 year-old man presented with a...

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We present a case of cytokeratin (CK) 20-positive large cell neuroendocrine carcinoma (LCNEC) presenting with multiple skin metastases as the primary manifestation. The patient was a 55-year-old man who presented with a one- month history of subcutaneous skin colored nodules of various sizes on his trunk. Pathologic examination of the skin revealed a nested and solid proliferation of large undi...