نتایج جستجو برای: sle
تعداد نتایج: 10032 فیلتر نتایج به سال:
the neuropsychiatric manifestations of systemic lupus erythematosus are frequent. one of the most serious presentations is convulsion. this study was carried out to evaluate the relation between convulsion and anti-dna antibody levels. an analytic, retrospective case-controlled study was carried out, with reference to 1001 recorded cases of systemic sle lupus erythematosus in lupus unit, rheuma...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, involves almost all organs such as skin, heart, kidneys and central nervous system. The disease is characterized by vascular and connective tissue inflammation in a recurring pattern of remission and flare. Although the exact pathophysiology of disease has not been fully understood yet, the fundamental defect in SLE is attribut...
Introduction: Systemic Lupus Erythematosus (SLE) is an autoimmune disease affect nearly every organ system. Pulmonary involvement, which is a common manifestation of SLE, can remain undiagnosed if asymptomatic. This study aimed to evaluate the efficiency of spirometric findings in early detection of silent pulmonary involvement and examine its correlation with the six minute walk test in SLE pa...
ضرورت این مطالعه از آنجا احساس می گردد که sle یکی از بیماریهای با انسیدانس 1/8 تا 7/6 در یکصد هزار نفر در سال و شیوع جنسی با نسبت زن به مرد حداقل 9 به 1 و حداکثر شیوع در سنی اواخر نوجوانی واوایل جوانی است . و بدن علیه سلولهای خودی آنتی بادی تولید کرده و دارای تنوع علایم بالینی و درگیری سیستم های مختلف می باشد. که تاکنون مطالعه کامل و دقیقی از شیوع - تظاهرات بالینی و آزمایشگاهی آن در دست نبوده ا...
The pathogenesis of systemic lupus erythematosus (SLE) is influenced by both genetic factors and epigenetic modifications; the latter is a result of exposure to various environmental factors. Epigenetic modifications affect gene expression and alter cellular functions without modifying the genomic sequences. CpG-DNA methylation, histone modifications, and miRNAs are the main epigenetic factors ...
Background & Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic inflammatory immune response. Current therapies mostly rely on glucocorticoids which are accompanied by side-effects and mostly fail to achieve a favorable remission. Th17 subpopulation of T cells is increased in exacerbated SLE as IL-17 cytokine is overexpressed. ...
مقدمه: ویتامین دی به عنوان یک فاکتور اتیولوژیک در تعدادی از بیماریهای اتوایمیون مثل مالتیپل اسکلروز، آرتریت روماتوئید و لوپوس اریتماتوزسیستمیک شناخته شده است.این مطالعه با هدف بررسی میزان شیوع کمبود ویتامین دی در بیماران مبتلا به sle انجام گرفت. مواد و روش ها: بیماران مبتلا به sle مراجعه کننده به کلینیک امام رضا و بیمارستان امیرالمومنین که براساس معیاری کلاسیفیکاسیون acr1997 تشخیص sle توسط روم...
systemic lupus erythematosus (sle) is a chronic autoimmune disease which results in damage to various organs. some animal studies have revealed that activation of toll-like receptors (tlrs) is important in the pathogenesis of sle. in the present study, the percentage of different immune cell subsets in 35 sle patients and 38 control subjects was analyzed by flow cytometry. we also assessed the ...
Systemic Lupus Erythematosus (SLE) is a chronic, life threatening systemic disorder that may affect multiple organs in the body. Dysfunction of the immune system, leading to over production of antibodies and immune complexes cause wide arrays of clinical feature. The classification criteria of SLE were updated in 2012. Treatment of SLE is individualized based on severity and extent of organ inv...
Background: Systemic Lupus Erythematosus (SLE) is a prototypic autoimmune disease with diverse clinical manifestations in association with autoantibodies to components of the cell nucleus. SLE as a chronic autoimmune disease has a worldwide distribution. There is a wide variation in the natural history of SLE among different ethnic and geographic groups. Our SLE registry is one of the largest s...
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