We developed BSP-SLIM, a new method for ligand-protein blind docking using low-resolution protein structures. For a given sequence, protein structures are first predicted by I-TASSER; putative ligand binding sites are transferred from holo-template structures which are analogous to the I-TASSER models; ligand-protein docking conformations are then constructed by shape and chemical match of liga...

The best arguments for the 1/3 answer to the Sleeping Beauty problem all require that when Beauty awakes on Monday she should be uncertain what day it is. I argue that this claim should be rejected, thereby clearing the way to accept the 1/2 solution. 1 Inertia and Sleeping Beauty If on Monday you confidently and rationally believe that Slippery Slim is guilty, and from Monday to Tuesday you ga...

With the current national emphasis on translational research, data-exchange systems that can bridge the basic and clinical sciences are vital. To meet this challenge, we have developed Slim-Prim, an integrated data system (IDS) for collecting, processing, archiving, and distributing basic and clinical research data. Slim-Prim is accessed via user-friendly Web-based applications, thus increasing...

BACKGROUND Scientific guidelines recommend the National Institutes of Health Stroke Scale for ischemic stroke assessment. However, many nurses find "slim" National Institutes of Health Stroke Scale versions or the Glasgow Coma Scale easier to use. OBJECTIVE To compare 3 "slim" versions of the National Institutes of Health Stroke Scale and the Glasgow Coma Scale with the full National Institut...

Structures for lossless ion manipulations (SLIM) have recently demonstrated the ability for near lossless ion focusing, transfer, and trapping in subatmospheric pressure regions. While lossless ion manipulations are advantageously applied to the applications of ion mobility separations and gas phase reactions, ion introduction through ring electrode ion funnels or more conventional ion optics t...

Development of complex systems is a collaborative effort spanning disciplines, teams, processes, software tools, and modeling formalisms. Increasing system complexity, reduction in available resources, globalized and competitive supply chains, and volatile market forces necessitate that a unified model-based systems engineering environment replace ad-hoc, document-centric and point-to-point env...