Radiopharmaceuticals are radioactively labeled compounds fulfilling the requirements of pharmaceutical products, used in radio diagnosis or radiotherapy. One essential parameter in the quality control of radiopharmaceuticals is the radionuclidic purity. In this work, we present aspects regarding the radionuclidic purity determination for the radiopharmaceutical products: Sodium Iodide (I) solut...

Key words protecting groups - selective deprotection cerium(III) chloride sodium iodide

Active transport of iodide into the thyroid gland is a crucial and rate-limiting step in the biosynthesis of thyroid hormones that play an important role in the metabolism, growth, and maturation of a variety of organ systems, in particular the nervous system (1). Although it has been known for decades that iodide transport into the thyroid gland is mediated by a specific sodium-dependent iodid...

Adequate iodide supply and metabolism are essential for thyroid hormones synthesis. In thyrocytes, iodide uptake is mediated by the sodium-iodide symporter, but several proteins appear to be involved in iodide efflux. Previous studies demonstrated that pendrin is able to mediate apical efflux of iodide in thyrocytes. Acute iodide excess transiently impairs thyroid hormone synthesis, a phenomeno...

Although it is beyond doubt that mammary cells accumulate iodide via a Na+-dependent transport mechanism, it is not clear if this is the only pathway for iodide transport in mammary tissue. In view of this, experiments were designed to test for the presence of an anion-exchange pathway which could mediate the transport of iodide into mammary cells; thus, the effect of external iodide on sulfate...

T was an eye-witness of the fruitful experiments conducted in the Headquarters Hospital of this district during 1924 by Lieut. E. A. Davies, t.m.d., and Assistant Surgeon Dr. P. Bell, r.M.D. (now Civil Surgeon). After taking over charge of this hospital I repeated these experiments on some patients of this subdivision and obtained good results. Unfortunately the Chins here do not consider goitr...

Rice rats were distributed by littermate into four experimental groups as follows: stannous fluoride (0.4%), iodine-sodium iodide (1.0%), a combination of iodine-sodium iodide and stannous fluoride, and a distilled water control. Each rat was treated by swabbing the molar teeth daily. All rats were fed diet 2000 and double-distilled water ad libitum, and were sacrificed after 9 weeks. Root surf...

The dehalogenation of a-haloketones and a-halocarbonyl compounds is an inevitable proce­ dure for the organic synthesis and these reductive dehalogenations have been often effected in organic syntheses. There have been various procedures for the purpose and these are obtained by zinc and acetic acid [1], sodium dithionite [2], titanium(III) chloride [3], organotin hydride [4], sodium hydrogen t...

An iodide ion-selective PVC membrane sensor based on copper (Π)-bis-Nphenilsalicyldenaminatocomplex as a novel sensing material is successfully developed. Theelectrode showed a good selectivity for iodide ion with respect to common inorganic anions. Thesensor exhibited a good linear response with slope of _58.6 ± 0.4 mV per decade over theconcentration range of 5.0 × 10-6 to 1.0 × 10-1 mol L-1,...