نتایج جستجو برای: solid lipid nanoparticle
تعداد نتایج: 375951 فیلتر نتایج به سال:
The androgen receptor plays a critical role in the progression of prostate cancer. Here, we describe targeting the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA designed to silence expression of the messenger RNA encoding the androgen receptor. Specifically, a Glu-urea-Lys PSMA-targeting ligand was incorporated into the lipid nanopart...
Solid Lipid Nanoparticle (SLN) merupakan sistem koloid pembawa untuk mengontrol perbaikan susunan kimia tubuh. SLN dapat meningkatkan kelarutan obat yang memiliki rendah dalam air dan juga pelepasan. Tujuan dari penelitian ini adalah melakukan analisis bibliometrik terhadap pengembangan sebagai drugs delivery dengan menggunakan pemetaan software VOSviewer. Data digunakan diperoleh dikumpulkan P...
The purpose of the present study was to optimize a solid lipid nanoparticle (SLN) of chloramphenicol by investigating the relationship between design factors and experimental data using response surface methodology. A Box-Behnken design was constructed using solid lipid (X(1)), surfactant (X(2)), and drug/lipid ratio (X(3)) level as independent factors. SLN was successfully prepared by a modifi...
colloidal carriers composed of lipids attract much attention in the development of safer and more effective therapy of various diseases. the advantages of lipid-based nanoparticles are illustrated on the example of paclitaxel, a challenging chemotherapeutic drug for the development of a novel and more suitable dosage form for cancer treatment. paclitaxel is known for its water insolubility and ...
Diclofenac sodium loaded solid lipid nanoparticles (SLNs) were formulated using guggul lipid as major lipid component and analyzed for physical parameters, permeation profile, and anti-inflammatory activity. The SLNs were prepared using melt-emulsion sonication/low temperature-solidification method and characterized for physical parameters, in vitro drug release, and accelerated stability studi...
The candesartan cilexetil belongs to class II of the biopharmaceutical classification system and bioavailability is 15% due to the poor aqueous solubility. The purpose of the study is to improve aqueous solubility by nano technology of solid lipid nanoparticle by solvent evaporation method. Here glyceryl monosterate (lipid), polaxemor 407, tweeen 80 (co-surfactant and surfactant respectively) a...
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