Small molecular reagents that can efficiently functionalize water soluble CdSe/ZnS nanocrystals (NCs) are reported. These reagents do not cause quenching or precipitation of NCs as seen with commercially available activators. The results demonstrate that controlling the electrostatic character of the materials is critical in the design of functionalization schemes.

The malachite green-molybdate reagent was used for a colorimetric assay of pure Mg2(+)-dependent phosphatidate phosphatase activity. This enzyme plays a major role in fat metabolism. Enzyme activity was linear with time and protein concentration, and with the concentration of water-soluble dioctanoyl phosphatidate. The colorimetric assay was used to examine enzyme inhibition by phenylglyoxal, p...

The effect of a cadaver-derived vascular plasminogen activator (VA) on the degradation of fibrinogen, soluble fibrin monomer, and fibrin was studied and compared with the effect of equivalent fibrinolytic potencies of streptokinase (SK), urokinase (UK), and plasmin. The proteolytic activity of the three activators and plasmin was determined by a standard fibrin plate assay and was expressed in ...

We have examined the relative roles of the macrophage (M phi) plasma membrane receptor for the cleaved third complement component (iC3b, CR3) and of the mannosyl/fucosyl receptor (MFR) in binding and ingestion of Leishmania donovani. In the absence of exogenous complement, the binding and ingestion of promastigotes, which are good activators of the alternative complement pathway, were inhibited...

Currently, there is an urgent need for domestic fermentation activators based on low-cost secondary raw materials. We aimed to study the effect of microbial enzyme preparations with different action hydrolysis proteins and phytin grain bran obtain that could become alternative imported ones.
 studied wheat rye brans; cytolytic, proteolytic, phytase action; multi-enzyme compositions; hydrol...

Pharmacological approach to heart failure with reduced ejection fraction (HFrEF) is evolving, as recently published large randomized clinical trials have implemented the disposal of HFrEF treatments four new classes drugs, namely angiotensin receptor/neprilysin inhibitor , sodium-glucose co-transporters 2 inhibitors soluble guanylate cyclase modulators and myosin activators, which proved furthe...

Abstract In this work the influence of alkaline activator on immobilization lead and copper in alkali-activated blast furnace slag was investigated. A total five alkali activators were used; sodium waterglass, potassium hydroxide, hydroxide carbonate. The leaching test according to ?SN EN 12457°-4 used evaluate level heavy metals, leached solutions analyzed by ICP-OES. For a better understandin...

This study shows that environmental confinement strongly affects the activation of nonlinear reaction networks, such as blood coagulation (clotting), by small quantities of activators. Blood coagulation is sensitive to the local concentration of soluble activators, initiating only when the activators surpass a threshold concentration, and therefore is regulated by mass transport phenomena such ...

Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO), which enhances GTP to cGMP conversion by sGC ~200-fold. The second messenger, cGMP, further modulates the activity of kinases and ion channels and ultimately induces smooth muscle relaxation and vasodilation. In cases of endothelial dysfunction, diminished NO production and insufficient output of the NOsGC-cGMP pathw...

Background The soluble guanylyl cyclase (sGC) is a key enzyme involved in the production of the second messenger cGMP. Due its cardiovascular relevance, sGC has been the target of numerous drug discovery efforts leading to the development of many different activators and stimulators with pharmaceutical potential. One of such compounds is the sGC activator Cinaciguat (BAY 58-2667) which is in cl...