purpose of this study was to investigate the effect of the presence of the water soluble polymers viz hpmc, pvp and peg 6000 on aqueous solubility and complexation abilities of felodipine with or without presence of β-cyclodextrin (βcd) and hpβcd by phase solubility studies. the data revealed the initial increase in drug solubility followed by plateau in the presence of relatively low polymer c...

Phosphate solublization activity of Bacillus subtilis in different carbon and nitrogen sources with insoluble form of phosphate sources like tricalcium phosphate and rock phosphate were studied. TCP solubilization with different carbon sources irrespective of incubation period can be related in the following order: glucose, fructose, arabinose, mannose, sucrose, lactose, and sorbitol. The pH dr...

In the present study, samples of rhizosphere and root nodules were collected from different areas of Pakistan to isolate plant growth promoting rhizobacteria. Identification of bacterial isolates was made by 16S rRNA gene sequence analysis and taxonomical confirmation on EzTaxon Server. The identified bacterial strains were belonged to 5 genera i.e. Ensifer, Bacillus, Pseudomona, Leclercia and ...

Synaptobrevin 2 is thought to facilitate fusion of synaptic vesicles with the presynaptic membrane through formation of a soluble NSF attachment protein receptor complex (SNARE) with syntaxin 1a and a synaptosomal associated protein of 25 kDa (SNAP-25). Previous reports have described a homodimer of synaptobrevin that is dependent on the transmembrane domain. However, these reports disagree abo...

Phosphorus is one of the major components required for the metabolic activities and for the growth of any organism. Many soil organisms are known to solubilize inorganic phosphates. Aspergillus niger isolated from the soil showed extensive solubilization of Tri-calcium phosphate.It was observed that the solubilization was due to drop in pH.Acidification was due to production of organic acids by...

DRM (detergent-resistant membranes), which are resistant to solublization by non-ionic detergents, have been demonstrated to be involved in many key cell functions such as signal transduction, endocytosis and cholesterol trafficking. Covalent modification of proteins by fatty acylation has been proposed to be an important protein-targeting mechanism for DRM association. However, little is known...

Adenylate cyclase [atp pyrophosphate-lyase (cyclizing): EC 4.6.4.4] activities were examined in mouse LM cell (fibroblast) membranes that were supplemented with ethanolamine and/or fatty acids. The supplements were incorporated into the plasma membrane phospholipids in significant amounts. Fatty acid supplementations had distinct effects as compared to polar head group supplementations. All lip...

Red Amaranth (Amaranthus tricolor) and green Amaranth (Amaranthus viridis) are two very important leafy vegetables consumed in most parts of India, not only for their flavours, but also for their pharmacological activities. The cooking processes are different in the different part of this country, and therefore, the present study was designed to analyze their in vitro antioxidant profile before...

Thyroglobulin, the precursor of thyroid hormones, is extracellularly stored in a highly condensed and covalently cross-linked form. Solublization of thyroglobulin is facilitated by cysteine proteinases like cathepsins B and K which are proteolytically active at the surface of thyroid epithelial cells. The cysteine proteinases mediate the processing of thyroglobulin by limited extracellular prot...

A laboratory test to differentiate the apparent availability of Mg among supplemental sources would be useful. Evaluation directly with cattle to test the reactivity, solublization (dissolution), and apparent absorption of Mg from various Mg sources in the rumen is tedious, laborious, and expensive. The degree of reactivity in the rumen and release of soluble Mg in the primary absorption site (...