Despite large-scale cancer genomics studies, key somatic mutations driving cancer, and their functional roles, remain elusive. Here, we propose that analysis of comorbidities of Mendelian diseases with cancers provides a novel, systematic way to discover new cancer genes. If germline genetic variation in Mendelian loci predisposes bearers to common cancers, the same loci may harbour cancer-asso...

BACKGROUND Psychiatric comorbidities are relevant for the diagnostic and therapeutic regimes in somatic hospital care. The main aim of this study was to analyse the association between psychiatric comorbidities and hospital costs per inpatient episode. A further aim was to discuss and address the methodological challenges in the estimation of these outcomes based on retrospective data. METHOD...

Long term antiepileptic drugs (AEDs) side effects are a common concern in people with epilepsy. AEDs are suspected to be associated with several somatic and psychiatric adverse events. This review focuses on long term somatic adverse events and the difficulties of assessing their exact association with AEDs. Most AEDs have been suggested to induce, at varying degrees, bone metabolism changes, i...

BACKGROUND Somatic comorbidities are a serious problem in patients with severe mental illnesses. These comorbidities often remain undiagnosed for a long time. In Germany, physicians are not allowed to access patients' health insurance data and do not have routine access to documentation from other providers of health care. Against this background, the objective of this article was to investigat...

BACKGROUND prior literature suggests that comorbidity with depression significantly worsens the health state of people with chronic diseases. OBJECTIVE the present study examines whether depressed mood increased medical care use for patients with a comorbid physical disease. DESIGN, SETTING AND SUBJECTS the study was a population-based study (KORA-Age), with 3,938 participants aged 64-94. ...

Mucous membrane pemphigoid (MMP) is a group of rare autoimmune blistering conditions mostly affecting the mucous membranes elderly people. National epidemiological data and larger studies on comorbidities MMP are scarce. We analyzed incidence in retrospective, case-control registry study all patients diagnosed specialized health care hospitals between 1996 2018 Finland (n=268). Also, specialtie...

Introduction Schizoaffective disorder is a mental health frequently associated with somatic and addictive comorbidities. This association can be dangerous as it may change the expression of disease its prognosis even affect quality life (QOL) overall functioning patients. Objectives study aimed to investigate impact comorbidities on QOL patients schizoaffective disorder. Methods paper cross-sec...

PURPOSE OF REVIEW Visceral pain represents a major clinical problem, yet far less is known about its mechanisms compared with somatic pains, for example, from cutaneous and muscular structures. RECENT FINDINGS In this review, we describe the neuroanatomical bases of visceral pain signalling in the peripheral and central nervous system, comparing to somatic pains and also the channels and rece...