In the present study, we aimed to determine localization and distribution of entero-endocrine cells in gastrointestinal tract by immunohistochemical methods understand structure glycoproteins elaborated epithelium digestive regions histochemical methods. The nine sparrowhawks were euthanized, tissues removed fixed formalin. sections stained with techniques evaluate enteroendocrine histomorphome...

Previous studies have suggested that somatostatin inhibits pancreatic secretion at a central vagal site, and the dorsal vagal complex (DVC) is involved in central feedback inhibition of the exocrine pancreas. The aim of this study was to investigate the effect of exogenous somatostatin in the DVC on pancreatic secretion and the somatostatin receptor subtype(s) responsible for the effect. The ef...

In order to examine whether somatostatin-28 originally isolated from porcine and ovine tissues was present in the human gut and pancreas or not, immunohistochemical methods using specific antisera against somatostatin-28 and somatostatin-14 antisera were carried out in the fetal and adult human gut and pancreas. The specific antisera against somatostatin-28 were prepared from somatostatin-28 an...

Abstract Radiation nephropathy is a rare complication following total body irradiation (TBI) and peptide receptor radionuclide therapy (PRRT). Yttrium 90-dotatoc (Y90) somatostatin analogue labelled with Y90 used for somatostatin-positive neuroendocrine tumours (NET). renally excreted has cumulative effect in the renal parenchyma Despite fractionation co-administration of renoprotective intrave...

Abstract Introduction: There are many studies about the inhibitory effect of the esophageal distention (ED) on gastric motility. Recently, it has been shown that ED decreases the gastric secretions. It is well established that the inhibitory effect of ED is mediated by activation of vago-vagal inhibitory reflex. However, there is not any investigation about the effect of the reflex on the gast...

solitary pulmonary nodule (spn) is a frequent finding on the chest x-ray and computed tomography. nuclear medicine techniques play an important role in the diagnosis and management of spn. in the current review, we briefly will explain the different nuclear medicine modalities in this regard including positron emission tomography (pet) using 18-f-fdg, and 11-c-methionine, and single photon emis...

Somatostatin and its analogs are active in the inhibition of SST receptor-positive endocrine neoplasms, but their activity and mechanism in nonendocrine tumors is not clear. Somatostatin potently inhibited growth of a Kaposi's sarcoma xenograft in nude mice, yet in vitro the tumor cells did not express any known somatostatin receptors and were not growth inhibited by somatostatin. Histological ...

Although the factors controlling the secretion of the neuropeptide somatostatin have been extensively studied, little is known about the mechanisms that control somatostatin biosynthesis. Somatostatin secretion is regulated by numerous agents that increase intracellular levels of cAMP. We sought to determine whether cAMP also regulates somatostatin mRNA accumulation. We found that forskolin eli...

abstract introduction: there are many studies about the inhibitory effect of the esophageal distention (ed) on gastric motility. recently, it has been shown that ed decreases the gastric secretions. it is well established that the inhibitory effect of ed is mediated by activation of vago-vagal inhibitory reflex. however, there is not any investigation about the effect of the reflex on the gastr...

OBJECTIVE There is growing evidence to indicate that somatostatin could be added to the list of natural antiangiogenic factors that exist in the vitreous fluid. In addition, a deficit of intravitreous somatostatin-like immunoreactivity (SLI) has been found in diabetic patients with proliferative diabetic retinopathy (PDR). In the present study, we have determined the main molecular variants of ...