The spasmolytic properties of the aqueous extract of Aframomum melegueta (K Schum) and Citrus aurantifolia (Christm and Panzer) (AMCA) mixture were tested on isolated rat trachea. Inhibition of the contraction was observed the in presence of the AMCA (EC 50 = 1.80 ± 0.48 mg/mL) after a pre contraction of the trachea by acetylcholine (10⁻⁵ M). With propranolol (10⁻⁶ M), the spasmolytic activity ...

The aqueous-ethanolic extract of the Hibiscus rosasinensis aerial parts (Hr.Cr) was studied for the possible presence of spasmogenic and spasmolytic constituents to rationalize some of its traditional uses in gastrointestinal disorders. Segments of isolated rabbit jejunum and guinea-pig ileum, 2-3 cm long were mounted seprately in Tyrode’s solution and aerated with 95% oxygen in carbon dioxide....

BACKGROUND The aqueous-methanolic extract of Amaranthus spinosus (A. spinosus Linn.,) whole plant, was studied for its laxative, spasmolytic and bronchodilator activities to validate some of its medicinal uses. METHODS The crude extract of A. spinosus was studied in-vivo for bronchodilator and laxative activities and in-vitro using isolated tissue preparations which were mounted in tissue bat...

hydroalcoholic extract of pycnocycla spinosa was shown to have spasmolytic action in vitro and antidiarrhoeal effect in vivo . the hydroalcoholic extract of p. spinosa is composed of alkaloid, flavonoid and saponin components. alkaloid fraction of p. spinosa contains the most active constituents. therefore, the aim of this research was to separate different fractions of alkaloid extract of p. s...

Aim. To investigate whether differences in the amounts of effective index components in Jakyak-Gamcho decoctions derived via extraction with either water or ethanol were associated with differential spasmolytic effectiveness. Methods. The amounts of effective index components (paeoniflorin, benzoic acid, glycyrrhizin, and isoliquiritin) contained in water-extracted Jakyak-Gamcho decoction and 7...

Purpose: Peristalsis of the small bowel leads to considerable movement artifacts in MR-examinations, which hamper diagnostic quality [1, 2]. Therefore a spasmolytic premedication agent is commonly administered intravenously to inhibit bowel motion, shortly before performing the abdominal imaging studies. Two main paralyzing agents, hyoscine N-butylbromide (HBB; Buscopan Boehringer Ingelheim, Ge...

In this paper we present the results of studying the effects of the essential oil of Calamintha glandulosa Silic (EOCG) on the isolated rat ileum. C. glandulosa Silic has been used in folk medicine as an antispasmodic. EOCG (0.003-1 mg/ml) inhibited spontaneous contraction of the ileum (EC50 of 210.48 +/- 9.12 microg/ml). The calcium channel blocking activity was confirmed by inhibition of K(+)...

The main objective of present study is to explore the hypotensive and GIT effect of traditionally important plant Cyperus rotudus. Aqueous extract of C. rotundus caused a decrease in mean arterial blood pressure in anaesthetized Sprague-Dawley rats in a dose dependant manner. At the dose of 3 mg/kg the MAB was found to reduce by 42.6% from its control. This fall in the MABP was statistically si...