background: therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs with an aim of minimizing unwanted radiation to surrounding healthy tissue. due to the potential of targeted radiotherapy to treat a wide range of malignant conditions, [153sm]-samarium maltolate was developed for possible therapeutic applications. materials and methods: the or...

BACKGROUND Most preclinical studies are carried out on mice. For internal dose assessment of a mouse, specific absorbed fraction (SAF) values play an important role. In most studies, SAF values are estimated using older standard human organ compositions and values for limited source target pairs. OBJECTIVE SAF values for monoenergetic photons of energies 15, 50, 100, 500, 1000 and 4000 keV we...

Background: Therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs with an aim of minimizing unwanted radiation to surrounding healthy tissue. Due to the potential of targeted radiotherapy to treat a wide range of malignant conditions, [153Sm]-samarium maltolate was developed for possible therapeutic applications. Materials and Methods: The or...

The knowledge of the absorbed radiation dose is essential in order to interpret the results of animal experiments with chronic ingestion of radionuclides by rodents. In order to evaluate this absorbed dose, we applied the dose conversion factors proposed by ICRP publication 108 to mouse chronic ingestion experiments with 20 kBq.L-1 137Csor 90Sr-contaminated water. The results indicated that who...

A Monte Carlo simulation of multiple trabecular bone cavities in adult bone was developed and the absorbed radiation dose factors evaluated for 3H and 14C. The model was developed to assess the dose from radionuclide uptake in quiescent bone, but also the effects of temporal changes in bone turnover by incorporating bone-modelling units (BMU). Absorbed dose fractions were calculated for target ...