Myocardial infarction with non-obstructive coronary arteries (MINOCA) is common and occurs in 6–8% of all patients fulfilling the diagnostic criteria for acute myocardial (AMI). This paper describes rationale behind trial ‘Randomized Evaluation Beta Blocker ACE-Inhibitor/Angiotensin Receptor Treatment (ACEI/ARB) MINOCA patients’ (MINOCA-BAT) need to improve secondary preventive treatment patien...

The inhibitory glycine receptor is a ligand-gated ion-channel protein existing in different homo- and heterooligomeric isoforms. Here we show that the chloride channel of the recombinant alpha 1-subunit homooligomeric glycine receptor is efficiently blocked by cyanotriphenylborate (CTB) with a concentration effecting 50% inhibition (IC50) of 1.3 microM in the presence of 50 microM glycine. The ...

In the skin of humans and rodents, local pressure induces localized cutaneous vasodilation, which may be protective against pressure-induced microvascular dysfunction and lesion formation. Once activated by the local pressure application, capsaicin-sensitive nerve fibers release neuropeptides that act on the endothelium to synthesize and release nitric oxide (NO) and prostaglandins, leading to ...

Abstract Introduction Landiolol is a recently innovated ultra-short-acting beta-blocker. the only beta-blocker with specific dose recommendation for patients cardiac dysfunction and acute atrial fibrillation (Class I according to ESC guidelines). has shorter elimination half-life than any other beta-blocker, it can be administered safely various tachyarrhythmias. The short duration of action ti...

OBJECTIVE To compare the effectiveness and associated costs of carbonic anhydrase inhibitors + beta-blocker versus alpha-2 adrenergic agonists + beta-blocker in glaucoma therapy, as documented by The United Kingdom General Practitioner Research Database (UK-GPRD). RESEARCH DESIGN Patient chart analysis. METHODS Patient records were screened for diagnoses of ocular hypertension or glaucoma, ...

BACKGROUND To investigate the association between post-diagnostic beta-blocker usage and risk of cancer-specific mortality in a large population-based cohort of female breast cancer patients. METHODS A nested case-control study was conducted within a cohort of breast cancer patients identified from cancer registries in England(using the National Cancer Data repository) and diagnosed between 1...