Neuron-specific enolase concentrations were measured in samples of rat cerebrospinal fluid obtained repeatedly before and after occlusion of the middle cerebral artery. A method for reliable, repeated sampling of cisternal cerebrospinal fluid was developed for this purpose. Occlusion of the middle cerebral artery induced cerebral infarcts of slightly variable size with good correlation to raise...

The development of a radioimmunoassay for S-100 protein is described. This method was used in combination with a recently developed radioimmunoassay for neuron-specific enolase in cerebrospinal fluid and serum from 47 patients with cerebral infarction, transient ischemic attack, intracerebral hemorrhage, subarachnoid hemorrhage, and head injury. In cerebrospinal fluid, increased concentrations ...

background and objective: neuroendocrine differentiation has not been proved to have effects in behavior of colorectal carcinomas. the aim of this study was immunohistochemical evaluation of neuroendocrine differentiation in colorectal cancer. patients and methods: in this cross-sectional study, 83 paraffin blocks from patients admitted in rasoul-e-akram hospital, tehran, iran, during 2003 to 2...

Enolase – a glycolytic enzyme is also expressed on the surface of eukaryotic cells such as macrophages, neutrophils, endothelial, neuronal, tumor cells. Surface enolase as plasminogen receptor plays an important role in myogenesis, tumorgenesis and angiogenesis. Determination of enolase localization in the cell lines may give rise to the elucidation of its receptor function in tumor cells. The ...

Febrile seizures are the commonest acute neurological disorder of early childhood. Studies suggested that febrile seizures are previous acute events from a more serious neurological problem. Due to neuron-specific enolase is generally accepted as a marker for neuropathological processes in the brain, 16 pediatric patients were studied during their first seizures and a year after it. Neuron-spec...

BACKGROUND AND OBJECTIVES Glycolysis is the sole source of energy for the intraerythrocytic stages of Plasmodium falciparum, making glycolytic enzymes putative therapeutic targets. Enolase, a single copy gene in P. falciparum is one such enzyme whose activity is elevated approximately 10-15 fold in infected RBC's. It holds the possibility of having multiple biological functions in the parasite ...

Alpha-enolase, also called non-neuronal enolase, belongs to a family of cytoplasmic and glycolytic enzymes. In addition to its glycolytic function, alpha-enolase exerts many other functions in eukaryotes and prokaryotes. Antibodies (Abs) against alpha-enolase have been detected in a large variety of infectious and autoimmune diseases. These Abs might arise as a consequence of a microbial infect...