OBJECTIVE This study aimed to explore the diagnostic role of a new dual receptor-targeted probe, integrin ανβ3 and gastrin releasing peptide receptor (GRPR) targeted peptide Glu-c(RGDyK)-bombesin (RGD-BBN) labeled with technetium-99m ((99m)Tc-RGD-BBN), using single photon emission tomography/computed tomography (SPET/CT) in the detection of breast tumor in comparison to ultrasound (US). SUBJE...

Thallium-201 chloride ((201)TlCl) is frequently used for imaging of a variety of malignant tumors viz., thyroid, lung, brain, bone and breast, however in patients with colorectal cancer, its role is not well established. In this case report we present three patients with colorectal cancer recurrence, with inconclusive computed tomography (CT) findings while (201)TlCl single photon emission tomo...

Reductions in regional cerebral perfusion, particularly in the posterior temporo-parietal lobes, are well recognized in Alzheimer's disease. We set out to correlate perfusion changes, using (99m)Tc-HMPAO single photon emission tomography (SPET), with the pathological stage of Alzheimer's disease. The 'Braak stage' of the distribution of neurofibrillary pathology in post-mortem brains was used t...

OBJECTIVES To compare the results of magnetic resonance imaging (MRI) and thallium-201 (201Tl) SPET scanning with laboratory analyses including CSF DNA detection, brain biopsy, and necropsy in the discrimination of cerebral lymphoma and toxoplasmosis in patients with AIDS. METHODS A retrospective study of 32 patients infected with HIV who had focal CNS lesions on MRI as a result of either lym...

These guidelines summarize the views of the European Association of Nuclear Medicine Neuroimaging Committee (ENC). The purpose of the guidelines is to assist nuclear medicine practitioners in recommending, performing, interpreting, and reporting the results of brain perfusion SPET studies using Tc-labelled radiopharmaceuticals. The aim is to achieve a high quality standard of brain perfusion SP...

Hellenic Journal of Nuclear Medicine January April 2011 www.nuclmed.gr 2 Figures 2 and 3. 131I-SPET study (Fig. 2) further clarified these foci in both kidneys. 18F-FDG-PET scan (Fig. 3) done on a separate day revealed abnormal foci of 18F-FDG uptake in the lower poles of both kidneys, corresponding to the foci seen on post treatment 131I-SPET. In the 18F-FDG-PET image, the foci can be well vis...

OBJECTIVE Coronary artery disease (CAD) is highly prevalent in patients with end-stage renal disease (ESRD), owing to clustering of traditional and uremic-specific risk factors. However, in this population asymptomatic course of CAD is common and it has been reported that myocardial perfusion imaging (MPI) with single-photon emission tomography (SPET) has lower sensitivity. In the current study...

Technetium-99m sulphur colloid (99mTc-SC) scintigraphy is a commonly used method in the assessment of peritoneopleuric leak in cases of liver insufficiency [1-4]. A 40 years old patient with alcoholic cirrhosis liver insufficiency, ascitis and hepatic encephalopathy was severely dyspnoic due to large right sided pleural effusion. A 99mTc-SC peritoneo-pleuric scintigraphy was performed. A 1.5 in...

BACKGROUND Myocardial perfusion imaging (MPI) with single photon emission tomography (SPET) is widely used in coronary artery disease evaluation. Recently major dosimetric concerns have arisen. The aim of this study was to evaluate if a pre-test scoring system could predict the results of stress SPET MPI, thus avoiding two radionuclide injections. METHODS All consecutive patients (n=309) unde...