The present work deals with the spherical crystallization process by Spherical agglomeration method applied to Zaltoprofen, a novel NSAID drug. The object of present study was to prepare and characterize the spherical agglomeration of water insoluble non-steroidal anti-inflammatory drug. Zaltoprofen spherical agglomerates prepared with poly ethylene glycol, which is hydrophilic polymer by using...

Felodipine is a second generation calcium channel blocker widely used as antihypertensive and antianginal drug which belongs to BCS class II category. Hence, its low water solubility limits the pharmacological effect. The aim of this study was to improve the dissolution rate of felodipine using spherical agglomeration technique with acetone, water and dichloromethane as good solvent, poor solve...

ABSTARCT:Emulsion Solovent Diffusion (EDS) technique combines crystallization and agglomeration directly to generate spherical agglomerates with improved micromeretic properties, thus obviating need for further processing by granulation and agglomeration. The present study was focused on spherical crystallization of an antifungal drug Gresiofulvine (GRV) using above mentioned ESD technique in w...

A simple thermodynamic analysis suggests that oil can spontaneously displace water from coal’s surface if the coal particle has a water contact angle greater than 90°. However, the clean coal products obtained from laboratory-scale dewatering-by-displacement (DbD) test work assayed moistures substantially higher than expected. These high moisture contents were attributed to the formation of wat...

Proteins are known to be effective building blocks when it comes to structure formation in aqueous environments. Recently, we have shown that submicron colloidal protein particles can also be used to provide structure to liquid oil and form so-called oleogels ( de Vries , A. J. Colloid Interface Sci. 2017 , 486 , 75 - 83 ) . To prevent particle agglomeration, a solvent exchange procedure was us...

Pulverized Wyoming subbituminous coal was beneficiated by low-pH oil agglomerationat CONSOL to prepare the coal for direct liquefaction. Conventional cleaning is not veryeffective in cleaning this coal; for example, conventional oil agglomeration only givesabout 20% ash rejection. To improve ash rejection, the coal-water slurry was acidifiedto a pH of about 0.5. Oil agglomeratio...

Pulverized Wyoming subbituminous coal was beneficiated by low-pH oil agglomerationat CONSOL to prepare the coal for direct liquefaction. Conventional cleaning is not veryeffective in cleaning this coal; for example, conventional oil agglomeration only givesabout 20% ash rejection. To improve ash rejection, the coal-water slurry was acidifiedto a pH of about 0.5. Oil agglomeratio...

Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small, free flowing, spherical or semi-spherical units, referred to as pellets. This review outlines manufacturing of spherical pellets. The manufacturing techniques include Drug layering, Extrusion-Spheronization, Cryopelletization, Compression, Balling, Hot-Melt Extrusion Technol...