The objective of this study was to develop solid self-emulsifying pellets to deliver the poorly bioavailable Milk Thistle extract (Silybum Marianum) [1]. These pellets were prepared via extrusion/spheronization procedure, using a self-emulsifying system or SES (composed of Akoline MCM, Miglyol, Tween 80, Soy Lecithin and Propylene Glycol), microcrystalline cellulose and lactose monohydrate. To ...

Abstract: Background/Objectives: The objective of the study was to examine feasibility extrusion/ spheronization techniques for formulation castor oil loaded self-emulsifying pellets. also aimed at optimization pellet system with design experiments. Materials and Methods: Various surfactants co-surfactants were tested their ability emulsify oil. proportion components (castor oil, surfactant co-...

The review focused on technique of solid self-emulsifying pellets (SEPs) for solubility enhancement poorly water soluble drug. oral route administration has been and still is currently the primary drug delivery owing to its potential advantages compared other routes. process hydrophobic drugs plays a key role in formulation development achieve bioavailability therapeutic action at target site.1...

Doxazosin mesylate (DXM) sustained release pellets were prepared by an extrusion-spheronization and fluid-bed coating technique. The core pellets containing DXM were prepared by extrusion-spheronization technique, and coated by a fluid-bed coater to control the release of DXM. The factors affecting to properties of pellets, such as diluent content, type and coating level of coating agents and p...

OBJECTIVES This study evaluates the effect of substitution of microcrystalline cellulose (MCC) with ethylcellulose (EC) on mechanical and release characteristics of theophylline pellets. MATERIALS AND METHODS The effect of addition of EC was investigated on characteristics of pellets with varying drug content prepared by extrusion-spheronization. Also the effect of type of granulating liquid ...

This paper reports the influence of post-melt impeller speed, post-melt processing time, binder concentration and particle size of bulk material on the sphericity of pellets produced by melt pelletization in a high shear mixer. Lactose was used as the bulk material with polyethylene glycol 3000 as a meltable binder. The sphericity of pellets was found to be affected by post-melt impeller speed ...

BACKGROUND AND THE PURPOSE OF THE STUDY Extrusion-spheronization is an established technique for the production of pellets for pharmaceutical applications. In this study, the feasibility and influence of the incorporation of acacia, by itself and in combination with tragacanth, on the ability of formulations containing 2 model of drugs (ibuprofen and theophylline) to form spherical pellets by e...

Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small, free flowing, spherical or semi-spherical units, referred to as pellets. This review outlines manufacturing of spherical pellets. The manufacturing techniques include Drug layering, Extrusion-Spheronization, Cryopelletization, Compression, Balling, Hot-Melt Extrusion Technol...