A simple and highly sensitive method that involves miniaturized hollow fiber assisted liquid-phase microextraction (HF-LPME) with in situ acyl derivatization and GC-MS was developed for the determination of benzophenone (BP) and related compounds in human urine samples. The limits of detection (S/N = 3) and quantification (S/N > 10) of BPs in human urine samples are 0.01 to 0.05 and 0.05 to 0.2...

Urine and plasma specimens fortified with 82 drugs and metabolites were prepared and analyzed by liquid chromatography quadrupole time-of-flight mass spectrometry (QTOF) instrumentation from three different vendors using the instrument manufacturers' methods and workflows for drug screening. No prior knowledge about the compounds included or their concentrations were provided. Samples were prep...

Thirteen antihistaminic drugs and their analogues are tested for their extraction by headspace solid-phase microextraction from human whole blood and urine. Their determination is made by using capillary gas chromatography with flame ionization detection. Relatively high recoveries are obtained for terodiline, diphenhydramine, diphenylpyraline, and orphenadrine in urine; but the recoveries in b...

background and objectives: analytical methods for volatile organic compounds (vocs) in different samples need extraction of compounds, by applying hazardous solvents. solid phase micro-extraction (spme) is a solvent-free equilibrium extraction method, in which proper calibration can allow quantitative determinations of vocs at a very good sensitivity without the use of any organic solvent. vocs...

background: determination of organic pollutants usually requires extraction of the pollutants from samples, using hazard­ous solvent. solid phase micro-extraction (spme) is a solvent-free equilibrium extraction method, in which, proper calibra­tion can allow quantitative measurements of organic pollutants at a very good sensitivity without the use of any organic sol­vent. because individual voc...

A water-soluble deep cavitand recognized alkylammonium salts, including the drug amantadine hydrochloride, in spiked samples of human urine. The signals of the guests are detected by (1)H NMR upfield of 0 ppm and so occur in a spectroscopic window that is outside of the normal region and distinct from the signals of the biofluid components.

A simple and sensitive spectrophotometric method was developed and validated for the determination of Theophylline (TH) in pharmaceutical dosage form as well as in human saliva and urine samples. This method is based on the measurement of absorbance of TH in Phosphate Buffer 6.8 at 270 nm. Beer’s law is obeyed over the range of 2-10 μg/ml. This method was used successfully for the quality asses...