Background: Following spinal cord injury, reactive astrocytes upregulate chondroitin sulfate proteoglycans (CSPGs) which act as a barrier to neuronal repair and regeneration. Therefore, enzymatic digestion of CSPGs by chondroitinase ABC (cABC) is a key strategy in the treatment of spinal cord injury. Furthermore, cABC has been shown to attenuate post spinal cord injury inflamma...

spinal cord injury (sci) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. the pathophysiology of acute spinal cord injury (sci) involves primary and secondary mechanisms. neuroinflammation is an important secondary injury process in sci. the local inflammatory microenvironment within the injured spinal cord ...

introduction: spinal cord injuries are accompanied with significant demyelination of axons and subsequent locomotor dysfunction. to identify the extent of damage following electrolytic lesion of ventrolateral white matter, essential area for initiation of locomotor activity, we assessed demyelination as well as alteration in motor performance. moreover, the protective effect of estradiol as a c...

a high number of people in the world suffered from spinal cord injury (sci). spinal cord injuries are happen due to falls from height, accidents, climbing, sports and etc. emergency care according to the standards not performed immediately after sci. a significant enhancement in the number of mortality and complications was observed every year. the aim of this study is to prevent the mortality,...

to date, various approaches have been used in attempt to treat spinal cord injury (sci) but there is no definite treatment for repair of the damaged tissue. it is well known that sci results in a loss of neural tissues and formation of cystic cavities that inhibit regeneration of axons. tissue engineering, in which cells, signals and scaffolds are combined, is one of the most promising areas of...

although spinal cord injury (sci) is one of the most common injuries after a road accident, there is no definite treatment for it. in this regard, nanotechnology has focused to retrieve damaged tissue function by designing of a biomaterial as a mimicking extracellular matrix to reduce inflammation, scar and lactate dehydrogenase, to fill the cyst and improve the graft integration, cell prolifer...

Spinal cord injury is a devastating chronic condition resulting in temporary or permanent motor,sensory or autonomic dysfunction of the cord. The manifestation of spinal cord injury based onthe severity and involved areas could be different. Numerous studies have demonstrated thatbradycardia, hypotension, and orthostatic hypotension are present insignificant number ofpat...

Spinal cord injury (SCI) is damage to the spinal cord that leads to sudden loss of motor and autonomic function and sensory under the level of the injury. Studies showed that individuals with SCI has a clear tendency to vitamins level change. The aim of this study was to review the vitamins level in spinal cord injury. Vitamins C level decrease in the injured spinal cord patient. Vitamins C hav...

background: over the years, various types of orthoses have been designed to assist subjects with spinal cord injury (sci) to stand and walk. however, the functional performance of the orthoses has not been adequate, that is, patients experience stability problems, consume excessive energy during ambulation, and generally require assistance in donning and doffing the devices. this research is ai...

o bjective: to describe the epidemiological characteristics of patients with cervical spine injury admitted to rajaee hospital, shiraz, iran. m e thods: this cross-sectional study includes all patients admitted with impression of cervical column injury with or without cervical cord injury from october 2009 to march 2012 to our level i trauma center in shiraz. we recorded the patients’ character...