Reinforced concrete (RC) frames are an integral part of modern construction as they resist both gravity and lateral loads in beams columns. However, the methodologies RC vulnerable to non-engineering defects, particularly developing countries. The most common defect occurs due improper lap splice, which can compromise structural integrity. This research demonstrates easy, low-cost, verifiable e...

abstract background and aim: survivin is a new member of inhibitor of apoptosis protein family (iap) that plays an important role in the regulation of cell cycle and inhibition of apoptosis. distinct expression of this gene in tumoral cells versus normal cells introduces it as the fourth major transcriptome in cancers. thyroid carcinoma is the most common endocrine malignancy. considering the h...

Abstract RNA splicing, and variations in this process referred to as alternative are critical aspects of gene regulation eukaryotes. From environmental responses plants being a primary link between genetic variation disease humans, splicing differences confer extensive phenotypic changes across diverse organisms (1–3). Regulation occurs through differential selection splice sites reaction, whic...

Prestressed, precast concrete piles using High-Strength Steel Strands (PPCPs HSSS) are a new type of pile. Compared with prestressed high-strength (PHC) piles, the adoption ultra-high-strength and HSSS not only improves load-bearing capacity, but also enhances ductility piles. The engineering application PPCPs requires high bearing capacity pile segments, reliable splicing to ensure cooperation...

Background: The study of specific genes expressed in the testis is important to understanding testis development and function. Spermatogenesis is an attractive model for the study of gene expression during germ cell differentiation. Spermatogenesis associated-19 (Spata-19) is a recently-identified important spermatogenesis-related gene specifically expressed in testis. Its protein product is in...

Nucleic acid therapeutics have demonstrated an impressive acceleration in recent years. They work through multiple mechanisms of action, including the downregulation gene expression and modulation RNA splicing. While several drugs based on former mechanism been approved, few target latter, despite promise splicing modulation. To improve our ability to discover novel splicing-modulating therapie...

background: the study of specific genes expressed in the testis is important to understanding testis development and function. spermatogenesis is an attractive model for the study of gene expression during germ cell differentiation. spermatogenesis associated-19 (spata-19) is a recently-identified important spermatogenesis-related gene specifically expressed in testis. its protein product is in...

The quality of grouted sleeve has a significant influence on the performance splice. Incompactness infilled grout is inevitable in grouting. To investigate tensile behavior splice sleeves due to different compactness, monotonic tests connectors were performed at compactness 100%, 90%, 70%, and 50%, respectively. bond-slip analytical model rebar-grout was deduced by fitting test data, formula fo...

Abstract Background Introns are generally removed from primary transcripts to form mature RNA molecules in a post-transcriptional process called splicing. An efficient splicing of is an essential step gene expression and its misregulation related numerous human diseases. Thus, better understand the dynamics this perturbations that might be caused by aberrant transcript processing it important q...

Objective(s): The use of antisense oligonucleotides (AOs) to restore normal splicing by blocking the recognition of aberrant splice sites by the spliceosome represents an innovative means of potentially controlling certain inherited disorders affected by aberrant splicing. Selection of the appropriate target site is essential in the success of an AO therapy. In this study, in search for a splic...