Abstract Few work concerned on the flexural strength of carbon fiber reinforced plastic (CFRP)-aluminum fuselage frames with bolted splice joints used in aeronautical industry. To provide help for design CFRP aircraft strcutures, this paper investigated behavior CFRP-aluminum experimentally. Firstly, were fabricated mid-span joints. The comprised: or unreinforced aluminum plates to frames. bolt...

Abstract Hollow section braces are often adopted in steel frame structures because of their superior performance. To connect tubular members with framing elements, field-bolted connections the slotted-in single splice plate and gusset majorly used ease construction. However, eccentricity between axes reduces compressive strength brace induces local connection failures under seismic excitations....

hypohidrotic ectodermal dysplasia (hed) is a rare congenital disorder arising from deficient development of ectoderm-derived structures including skin, nails, glands and teeth. the phenotype of hed is associated with mutation in eda, edar, edaradd and nemo genes, all of them disruptingnf-κb signaling cascade necessary for initiation, formation and differentiation in the embryo and adult. here w...

Human insulin-like growth factor 1 Ec (IGF-1Ec), also called mechano growth factor (MGF), is a splice variant of insulin-like growth factor 1 (IGF-1), which has been shown in vitro as well as in vivo to induce growth and hypertrophy in mechanically stimulated or damaged muscle. Growth, hypertrophy and responses to mechanical stimulation are important reactions of cartilaginous tissues, especial...

Splice regulators play an essential role in the transcriptomic diversity of all eukaryotic cell types and organ systems. Recent evidence suggests a contribution splice-regulatory networks many diseases, such as cardiomyopathies. Adaptive splice regulators, RNA-binding motif protein 20 (RBM20) determine physiological mRNA landscape formation, rare variants RBM20 gene explain up to 6% genetic dil...