نتایج جستجو برای: splicing component sc 35

تعداد نتایج: 834938  

Journal: :The Journal of Cell Biology 2007
Kelly P. Smith Meg Byron Carol Johnson Yigong Xing Jeanne B. Lawrence

In myotonic dystrophy type 1 (DM1), triplet repeat expansion in the 3' untranslated region of dystrophia myotonica protein kinase (DMPK) causes the nuclear retention of mutant messenger RNA (mRNA). Although the DMPK gene locus positions precisely at the outer edge of a factor-rich SC-35 domain, the normal mRNA consistently accumulates within the domain, and this RNA is depleted upon transcripti...

Journal: :The Journal of Cell Biology 1995
Y Xing C V Johnson P T Moen J A McNeil J Lawrence

This work demonstrates a highly nonrandom distribution of specific genes relative to nuclear domains enriched in splicing factors and poly(A)+ RNA, and provides evidence for the direct involvement of these in pre-mRNA metabolism. As investigated in hundreds of diploid fibroblasts, human collagen I alpha 1 and beta-actin DNA/RNA showed a very high degree of spatial association with SC-35 domains...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1992
S Huang D L Spector

The localization of U1 and U2 small nuclear RNAs (snRNAs) has been examined by in situ hybridization using 2'-O-alkyl oligonucleotide probes. We have found that these snRNAs, which are essential for pre-mRNA splicing, localize in a speckled distribution, in addition to being present in three of four foci, in HeLa cell nuclei. However, in cells of defined passage, such as Detroit 551 and WI-38 f...

Journal: :European journal of histochemistry : EJH 2002
C Soldani M G Bottone M Biggiogera C Alpini A I Scovassi T Martin C Pellicciari

Using immunocytochemical techniques at light and electron microscopy, we analysed the distribution of phosphorylated c-Myc in actively proliferating human HeLa cells. The distribution pattern of c-Myc was also compared with those of other ribonucleoprotein (RNP)-containing components (PANA, hnRNP-core proteins, fibrillarin) or RNP-associated nuclear proteins (SC-35 splicing factor). Our results...

2017
Raphaël Saffroy Vincent Fallet Nicolas Girard Julien Mazieres Denis Moro Sibilot Sylvie Lantuejoul Isabelle Rouquette Françoise Thivolet-Bejui Thibaut Vieira Martine Antoine Jacques Cadranel Antoinette Lemoine Marie Wislez

MET exon 14 splicing mutations are new targetable oncogenic drivers reported in 3% of non-small cell lung cancer (NSCLC) cases and have been shown to be more common in pulmonary sarcomatoid carcinomas (PSCs). This study sought to screen mutations affecting MET exon 14 splice sites in a large SC cohort of Caucasian patients, with a large adenocarcinoma cohort as internal control.We tested 81 pat...

Journal: :Neuron 2001
Joshua D. Berke Véronique Sgambato Peng-Peng Zhu Brigitte Lavoie Michel Vincent Michael Krause Steven E. Hyman

Control of neuronal gene expression by drugs or neurotransmitters is a critical step in long-term neural plasticity. Here, we show that a gene induced in the striatum by cocaine or direct dopamine stimulation, ania-6, is a member of a novel family of cyclins with homology to cyclins K/T/H/C. Further, different types of neurotransmitter stimulation cause selective induction of distinct ania-6 is...

Journal: :The Journal of general virology 1999
M Cooper D J Goodwin K T Hall A J Stevenson D M Meredith A F Markham A Whitehouse

The herpesvirus saimiri (HVS) gene product encoded by ORF 57 shares limited C-terminal similarity with herpes simplex virus 1 ICP27, a protein that has been demonstrated to be involved in the inhibition of host-cell splicing and is responsible for the redistribution of components of the spliceosome. It has previously been shown that ORF 57 can either activate or repress viral gene expression by...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1996
S Lopato A Mayeda A R Krainer A Barta

The fact that animal introns are not spliced out in plants suggests that recognition of pre-mRNA splice sites differs between the two kingdoms. In plants, little is known about proteins required for splicing, as no plant in vitro splicing system is available. Several essential splicing factors from animals, such as SF2/ASF and SC-35, belong to a family of highly conserved proteins consisting of...

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