Designing simple mechanisms with desirable revenue guarantees has become a major research agenda in the economics and computation community. However, few mechanisms have been actually applied in industry. In this paper, we aim to bridge the gap between the “simple versus optimal” theory and practice, and propose a class of parameterized mechanisms, tailored for the sponsored search auction sett...

BACKGROUND Reporting of pharmaceutical-industry-sponsored randomised clinical trials often result in biased findings, either due to selective reporting of studies with non-equivalent arms or publication of low-quality papers, wherein unfavourable results are incompletely described. A randomised trial should be conducted only if there is substantial uncertainty about the relative value of one tr...

example, are not represented in theDiagnostic and Statistical Manual of Mental Disorders (DSM) criteria.3 In evaluating the desirability of screening for depression in primary care, it is tempting, but in our view amistake, to reify theDSM criteria. This line of reasoning risks losing sight of a deeper reality: the criteria formajor depression arenot the thing itself, but rather an imperfect in...

Joal Hill I read with interest the debate about for-profi t versus non-profi t institutional review boards (IRBs) [1], but was disappointed that no one addressed the ability (or inability) of for-profi t IRBs to review studies with the local context of research subjects in mind and then monitor what actually occurs during the consent process throughout the research trial. To my mind the “bignes...

We systematically overview the literature in keyword search and propose several promising research directions. The paper is organized by each agent in the search process; searchers, advertisers and the search engine and reviews the key research issues for each. For each group, we outline the decision process involved in keyword search. For searchers, this involves what to search, where to searc...