A new approach to the fabrication of individual implants and scaffolds for tissue engineering—surface selective laser sintering (SSLS)—is proposed and realized. In contrast to the conventional selective laser sintering, the SSLS method makes it possible to sinter polymer microparticles and melt the near-surface layer rather than the microparticle as a whole. The effect of the laser radiation pa...

Targeting hepatic stellate cells (HSCs) has been challenging due to the lack of specific receptors or motifs on the cells. The aim of the present study was to develop a HSC-specific system for improving drug delivery to HSCs. The affinity of a cyclic peptide containing Arg-Gly-Asp (cRGD) to collagen type VI receptor on HSCs was examined in both in vitro and in vivo experiments. Sterically stabl...

Shikonin (SHK) has been proven to have a good anti-tumor effect. However, poor water solubility and low bioavailability limit its wide application in clinical practice. In this study, to overcome these drawbacks, RGD-modified shikonin-loaded liposomes (RGD-SSLs-SHK) were successfully prepared. It exhibited excellent physicochemical characteristics including particle size, zeta potential, encaps...

Bowel cancer screening programmes have highlighted to endoscopists and clinicians the spectrum of serrated colorectal lesions. One of the most significant developments has been the recognition that sessile serrated lesions (SSLs), while bearing histological resemblance to hyperplastic polyps (HPs), may be associated with the enhanced development of epithelial dysplasia and colorectal adenocarci...

Synthetic sickness/lethality (SSL) can be exploited to develop therapeutic strategies for cancer. Deficiencies in the tumor suppressor proteins MLH1 and MSH2 have been implicated in cancer. Here we demonstrate that deficiency in MSH2 is SSL with inhibition of the DNA polymerase POLB, whereas deficiency in MLH1 is SSL with DNA polymerase POLG inhibition. Both SSLs led to the accumulation of 8-ox...

During the last few years consumer behavior has significantly changed. Implementation of self- service technologies (SSLs) influenced interactions between and retailer. Thanks to current situation, where social contacts are being restricted, use SSLs is growing. Due this trend, there a greater need evaluate impact those technology on behavior. Objective article review available research satisfa...

Schizotypy has been proposed to be the expression of the genetic vulnerability to schizophrenia. Schizotypal features have been associated with personality dimensions found in patients with psychosis. In this study, we compared the Dimensional Assessment of Personality Pathology - Basic Questionnaire (DAPP-BQ) scores of patients with psychosis, siblings scoring higher on schizotypy (SSHS), and ...

The XDD beamline (http://ssls.nus.edu.sg/facility/beamlines/xdd/xdd.htm) at SSLS delivers a tunable monochromatized photon source with high resolution in a wide energy range (2.3-10 keV). This hard x-ray light source is ideal for diffractometry, fluorescence detection and absorption spectroscopy, especially the study of XAFS (x-ray absorption fine structure) and XANES ( X-ray Absorption Near Ed...

Macrophytes are key to the functioning of small shallow lakes (SSLs) because they maintain a clear water state through numerous positive feedbacks. The composition macrophyte communities changes under anthropogenic pressures; as result, tools designed easily and rapidly assess their structure increasingly requested. We tested three sampling methods (the S3m method, stratified mapped inventory) ...