Depression during pregnancy occurs frequently and selective serotonin reuptake inhibitors (SSRIs) are often the drug of choice when treating pregnant women. Most published studies found no increased risks of congenital malformations in association with SSRIs, but there are reports of various malformations for SSRIs as a group and for specific SSRIs. To assess potential adverse effects of SSRIs ...

The controlled studies of selective serotonin reuptake inhibitors (SSRIs) in pediatric psychopharmacology research lag behind the controlled studies of SSRIs in adults. As a result, widespread use of SSRIs in the treatment of child and adolescent psychiatric disorders is in stark contrast to the paucity of research data. Recent changes in the research climate (including support from the Nationa...

This paper examines the controversy over the use of selective serotonin-reuptake inhibitors (SSRIs) in the treatment of children and adolescents. Arguments for and against the use of SSRIs with pediatric populations are evaluated. Supporting SSRI treatment are findings that SSRIs are effective, the potential accessibility of medication, and findings that SSRIs have played a role in the overall ...

QUESTION Functional gastrointestinal disorders (FGIDs) are complex conditions I see in some of my pediatric patients. The indications for antidepressants such as selective serotonin reuptake inhibitors (SSRIs) do not include treatment of FGIDs; however, some children are prescribed SSRIs for this condition. Are antidepressants effective and safe to use for treating FGIDs in children and adolesc...

BACKGROUND It is unclear whether the use of selective serotonin reuptake inhibitors (SSRIs) and other antidepressant drugs reduce the risk of suicide in people with depression. We explored the association between exposure to SSRIs and risk of suicide completion or attempt. METHODS We conducted a systematic review of observational studies that reported completed or attempted suicide in depress...

We investigate how the prescribing behavior of physicians reacts to scientific information and recommendations released by public authorities. Taking example antidepressant drugs, we use French panel data on exhaustive prescriptions made a representative sample general practitioners more than 110,000 depressed patients between 2000 2008. New results revealing an increase in suicidal thinking am...

OBJECTIVE We compared functional impairment outcomes assessed with Sheehan Disability Scale (SDS) after treatment with duloxetine versus selective serotonin reuptake inhibitors (SSRIs) in patients with major depressive disorder. METHODS Data were pooled from four randomized studies comparing treatment with duloxetine and SSRIs (three double blind and one open label). Analysis of covariance, w...