1 N. Maffulli, MD, MS, PhD, FRCS Orth, Professor Department of Trauma and Orthopaedic Surgery, Keele University School of Medicine, North Staffordshire Hospital, Thornburrow Drive, Hartshill, Stoke-on-Trent, Staffordshire ST4 7QB, UK. D. Kader, FRCS, Specialist Registrar Department of Orthopaedic Surgery, University of Aberdeen Medical School, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD,...

Tumor necrosis factor alpha (TNFalpha) may induce tumor cell death by apoptosis, the physiologic program of cell death usually lost during neoplastic progression. However, many tumor cells are resistant to its effect unless high doses are administered. By retroviral vector-mediated gene transfer, we have transduced the TNFalpha gene into the DNA of human tumor cells to investigate whether the i...

The efficacy of the serotype 3 (ST3) pneumococcal conjugate vaccine (PCV) remains unclear. While the synthesis of capsular polysaccharide (CPS) of most serotypes is wzy dependent, the strains of two serotypes, 3 and 37, synthesize CPS by the synthase-dependent pathway, resulting in a polysaccharide that is not covalently linked to peptidoglycan and can be released during growth. We hypothesized...

SUZY STOKES, NICK S. KALSON, MARK EARL, ADAM G. WHITEHEAD, IAN TYRRELL-MARSH, HANNAH FROST, ANDREW DAVIES Clinical Education Centre, University Hospital of North Staffordshire, Stoke-on-Trent ST4 6QG, UK Manchester University Medical School and MARS—Manchester Altitude Research Society, The Medical School, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PL, UK Hope Hos...

conclusions the prevalence of b. hominis in the study area was lower than that reported for most developed countries, and unlike in other countries in the middle east, st4 was the most prevalent subtype. results blastocystis hominis was found to have a prevalence of 3.33% in the study population. there was no significant association of blastocystis infection with age (p = 0.3) or gender (p = 0....

The intestinal protistan parasite Blastocystis is characterized by an extensive genetic variability with 17 subtypes (ST1-ST17) described to date. Only the whole genome of a human ST7 isolate was previously sequenced. Here we report the draft genome sequence of Blastocystis ST4-WR1 isolated from a laboratory rodent at Singapore.

1Department of Environmental Science, Vytautas Magnus University, K. Donelaicio 58, LT-44248 Kaunas, Lithuania 2Department of Cardiology, Lithuanian University of Health Sciences, Eiveniu 2, LT-50167 Kaunas, Lithuania 3Institute of Cardiology, Lithuanian University of Health Sciences, Eiveniu 2, LT-50167 Kaunas, Lithuania 4Centre for Research in Environmental Epidemiology (CREAL), Doctor Aiguad...

Conventional Protein Kinase C isoforms differentially regulate ADPand thrombinevoked Ca signalling in human platelets Robert A. Lever, Azhar Hussain, Benjamin B. Sun, Stewart O. Sage & Alan G.S. Harper Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom and Institute for Science and Technology in Medicine, Keele Uni...

Keele University and University Hospital of North Staffordshire, Staffordshire, UK David Geffen School of Medicine at UCLA, Department of Obstetrics and Gynecology, Box 951740, Los Angeles, CA, USA National Aging Research Institute, Department of Psychiatry, University of Melbourne, Vic, Australia Keele University, Institute of Science and Technology in Medicine, Guy-Hilton Research Centre, Sto...

Prediction of severe natural hazards requires accurate forecasting systems. Recently, there has been a tendency towards more integrated solutions, where different components the Earth system are coupled to explicitly represent physical feedbacks between them. This study focuses on rapidly developing waves under extratropical storms understand impact wave source term parameterisations in WAVEWAT...