A novel stability-indicating high-performance liquid chromatographic assay method was developed and validated for valacyclovir in the presence of degradation products generated from forced decomposition studies. A Hypersil ODS C-18 (250 x 4.6 mm, packed with 5 micron) column in an isocratic mode with the mobile phase acetonitrile: phosphate buffer (pH3.6) (50:50%v/v) was used. The flow rate was...

A simple, selective, precise and stability-indicating high-performance thin layer chromatographic method of analysis of meloxicam both as a bulk drug and in formulation has been developed. The mobile phase selected was ethyl acetate:cyclohexane:glacial acetic acid (6.5:3.5:0.02% v/v/v). The calibration curve of the drug was linear in the range of 100-500 ng. The spectrodensitometric analysis wa...

a simple and rapid stability indicating method based on capillary zone electrophoresis has been developed and validated for the analysis of buserelin (bus). the best separations were achieved by using a bare fused silica capillary (75 m i.d.; 65.5 cm total, 57.0 cm effective length), phosphate buffer (ph = 3.00; 26.4 mm), at 35 °c. the sample was hydrodynamically injected at 50 mbar for 5 seco...