Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

aim: to enhance the aqueous solubility of olanzapine by using the solid dispersion technique. solid dispersions of olanzapine were prepared by the dispersion method using using pgs and ssg as carriers. drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

date syrup powder is a new product which can be used as sugar substitute. first, the date syrupwas spread out on a foil and placed in the oven at 60°c for 24 hours. date syrup was separated from the foil andgrinded. 2% agar and 2% starch were added and syrup with agar and starch that was in a lumpy shape werecrushed and spread on the foil and placed at 60°c for 24 hours. powdered granules, agar...

Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

The objective of the study is to prepare, characterize and evaluate starch phosphate, a new modified starch as a carrier in solid dispersions for enhancing the dissolution rate of ritonavir. The feasibility of formulating solid dispersions of ritonavir in starch phosphate into compressed tablets with enhanced dissolution rate was also investigated. Starch phosphate was prepared by reacting star...

Modified starch is synthesized to change the physical and chemical properties, one of which solubility. Two new things were produced in substitution process, namely modifications final stage (workup) reaction each substituent, changes neutralization stage/carboxymethyl solids using 30% CH3COOH use methanol pro-analyst sulfonate deposition process. The results solubility test showed that at room...

BACKGROUND Cassava starch, the economically important agricultural commodity in Thailand, can readily be cast into films. However, the cassava starch film is brittle and weak, leading to inadequate mechanical properties. The properties of starch film can be improved by adding plasticizers and blending with the other biopolymers. RESULTS Cassava starch (5%w/v) based films plasticized with glyc...

Purpose: This investigation was carried out to determine the impact of Parkia biglobosa starch modification on the fractions, namely rapidly digestible starch (RDS), slowly digestible starch (SDS), and resistant starch (RS). Methods: Aqueous solution of sodium hypochlorite and potassium hydroxide was used to extract starch prior to modification by pyrodextrinization, cross-linking and heat-mois...

Replacement of plastics used in the food industry seems to be a serious issue to overcome mainly the environmental problems in recent years. This study investigates the hydrophilicity and permeability properties of starch biopolymer which ethylene vinyl alcohol (EVOH) (0-10%) and nanocrystalline cellulose (NCC) (1-15%) were used to enhance its properties. Starch -EVOH nanocomposites were prepar...

The effects of heat treatment on oat and barley starch water dispersions were investigated. As compared with barley starch, the granules from oat starch were more degraded, but the fractionation patterns of both starches were not significantly different. Microscopic examination indicated that no evidence of amylopectin fragments was observed in the liquid fraction after starch dispersions were ...