Atherosclerosis (AS) causes cardiovascular disease, which leads to fatal clinical end points like myocardial infarction or stroke, the most prevalent causes of death in developed countries. An early, noninvasive method of detection and diagnosis of atherosclerotic lesions is necessary to prevent and treat these clinical end points. Working toward this goal, we examined recombinant interleukin-1...

At the turn of the 20th century, the German bacteriologist Paul Ehrlich coined the expression “magic bullets” in his search for chemotherapeutic agents with specific affinity for diseased tissues. Understanding target structure and function, developing drug delivery strategies to achieve controlled release, and targeting of drugs to specific tissues of the body have been a major focus of resear...

Liposome entrapment of doxorubicin has been shown to reduce its cardiotoxicity in vivo and increase its therapeutic index. A further im provement in therapeutic index could be achieved through targeting of liposome-entrapped drug selectively to cancer cells. Monoclonal anti bodies against the squamous lung cancer cell line KI N 205 have been ligated to the surface of long-circulating (Stealth) ...

Liposome entrapment of doxorubicin has been shown to reduce its cardiotoxicity in vivo and increase its therapeutic index. A further improvement in therapeutic index could be achieved through targeting of liposome-entrapped drug selectively to cancer cells. Monoclonal antibodies against the squamous lung cancer cell line KLN-205 have been ligated to the surface of long-circulating (Stealth) and...

Tc-99m was complexed with alpha-D-glucose-1-phosphate (DGP) using stannous chloride as a strong reducing agent. Stealth liposomes were prepared using Sphingomyelin (SM), Phosphatidylcholine (PC), Cholesterol (CH) and Monosialogangliosides (GM-1) in the ratio of SM: PC: CH: GM-1: 1:1:1:0.2 by the method of sonication. Tc-99m-DGP was entrapped in these vesicles and the radiolabelling efficiency w...

This review focuses on polymer- and liposome-based nanoparticles used in targeted delivery of bioactive molecules, from drugs to siRNA to pDNA. The perspective centers around commercial and clinical successes, and a rationalization of these successes. Microparticulate systems are not covered, and only those applications that truly utilize the advantages of nano size are covered. "Stealth" syste...

Pegylated liposomal doxorubicin (PLD, Doxil, Caelyx) is widely used for the treatment of ovarian cancer. It is a stable formulation encapsulating doxorubicin in a 'Stealth' (i.e., pegylated) liposome with a half-life of about 72 hours. This drastically altered pharmacology confers on it a considerably lower risk of cardiotoxicity, no acute emesis, and near absence of alopecia or problems with e...

Indium-111 (111In) and technetium-99m (99Tcm) Stealth liposomes were compared with 111In- and 99Tcm-labelled white blood cells (WBC) in experimental infection in a rabbit model. Preformed polyethylene glycol-coated liposomes and separated WBC were radiolabelled with either 111In-oxine or 99Tcm-hexamethylpropyleneamine oxime (99TcM-HMPAO). After the intravenous administration of one of the four ...

Liposome plays an important role in medical and pharmaceutical science as e.g. nano scale drug carriers. Liposomes are vesicles of varying size consisting of a spherical lipid bilayer and an aqueous inner compartment. Magnet-driven liposome used for the targeted delivery of drugs to organs and tissues. These liposome preparations contain encapsulated drug components and finely dispersed magneti...

Flurbiprofen (FP) is a phenyl alkanoic acid derivative and a family of non-steroidal anti-inflammatory drug used in the treatment of arthritis. The aim of this study was to prepare a new parenteral formulation for FP that can prolong the biologic half-life of the drug, improve its therapeutic efficacy, and reduce its associated side effects targeting the inflammation due to arthritis. PEG-ancho...