Phylogenetic methods are becoming part of the standard methodologies used in the analyses of biological sequence data, but several of the classical tools of phylogenetic inference were not designed with high throughput applications in mind. During our surveys, we haven't found software for the fast inference of neighbor joining trees from sequence alignments which could use biologically realist...

We present the explicit solution of the Bayesian problem of sequential testing of two simple hypotheses about the intensity of an observed Poisson process. The method of proof consists of reducing the initial problem to a free-boundary differential-difference Stephan problem, and solving the latter by use of the principles of smooth and continuous fit. A rigorous proof of the optimality of the ...