Total synthesis of the cyanobacterial metabolite largamide B and the disproval of its originally assigned stereochemistry as well as confirmation of the revised stereochemistry are reported.

Electric-field assisted free-radical polymerization allows controlling the stereochemistry of produced polymers.

The Glauciumpaucilobum Freyn population of the Golestan forest contained three major alkaloids; protopine (0.5%), ?-allocryptopine (0.2%), corydine (0.1 %), and six minor alkaloids; N-rnethyllind carpine (0.006), bulboca 'nine (0.04%), 4-hydroxy bulbocapnine (0.001%), Ismorycline (0.04%), arosine (0%02%) and corydine-?-Noxide (0.003%). N-methyllindcrapine, 4-hydroxybulbocapnine and corydine-...

A streamlined entry into the sesquiterpene lactone (SQL) cores of linearifolin and zaluzanin A is described. Stereochemistry is controlled through transformations uncovered by ISES (In Situ Enzymatic Screening). Absolute stereochemistry derives from kinetic resolution of 5-benzyloxypentene-1,2-oxide, utilizing a β-pinene-derived-Co(III)-salen. Relative stereochemistry (1,3-cis-fusion) is set vi...

The subject of stereochemistry in considered a difficult concept organic chemistry because its dependence on spatial ability. challenges that students face learning about can lead to poor performance and alternative conceptions, which turn might hinder their progresses various science engineering academic careers. Development successful conceptual understanding solve related problems requires h...

Herein we describe a scalable approach to the decalin moiety of maklamicin. Key to the synthesis is an intramolecular Diels-Alder (IMDA) reaction that proceeds via an endo-axial transition state to generate the desired stereochemistry. We explored the diastereoselectivity of the IMDA reaction as a function of both chiral catalysis and acyclic precursor stereochemistry.

Radical-mediated thiodesulfonylation of the vinyl and (α-fluoro)vinyl sulfones, derived from aldehydes and ketones, with aryl thiols in organic or aqueous medium provided access to vinyl and (α-fluoro)vinyl sulfides. The vinyl sulfides were formed predominantly with E stereochemistry independent of the stereochemistry of the starting vinyl sulfones.