Kopf stereotaxic, thereby enabling it to be adapted for use in retinal physiology. A fundamental requirement for all visual physiology is an unobstructed visual field. This can be partially achieved using the standard optical investigation unit, in which the animal faces the rear of the instrument. However, in this configuration, the zero horizontal meridian is still somewhat obstructed. This c...

Investigations of the cerebellar nuclei and the white matter adjacent to them have been very few in number as compared with many studies of cerebellar function based upon gross extirpation of this organ or upon destruction or stimulation of its cortex. It is well known, however, that the nuclei constitute at least the major source of all efferent cerebellar connections, and the small amount of ...

Magnetic resonance imaging (MRI) of six Yukatan minipig brains was performed. The animals were placed in stereotaxic conditions currently used in experiments. To allow for correctpositioning of the animal in the MRI instrument, landmarks were previously traced on the snout of the pig. To avoid movements, animal were anesthetized. The animals were placed in a prone position in a Siemens Magnetom...

MRI has achieved widespread use for preplanning neuroscience procedures for non-human primate studies. However, orienting imaging studies in stereotaxic space has relied primarily on using a stereotaxic frame or co-registering fiducial markers with the neuroimaging. In this study, we present a simple approach in which the MRI dataset is aligned to the bony landmarks that define the Frankfurt st...

A precision stereotaxic procedure for mouse brain research is described accompanied by a new design in mouse stereotaxic head holder and a new device used to guarantee accurate alignment of the skull in the stereotaxic device. This method and instrumentation when applied in forthcoming research will contribute to the development of investigations of structure/function relationship in mouse brain.

Computed tomographic (CT)-guided stereotaxic procedure have become established in a few major centers but a single optimal system has not yet emerged. At Duke University Medical Center, availability of a stereotaxic frame with design features that lend themselves to CT adaptation made modification of this unit, rather than construction of a new dedicated frame, cost-effective. As other centers ...