نتایج جستجو برای: sterol regulatory elementbinding transcription factor 1

تعداد نتایج: 3558966  

Journal: :The Journal of biological chemistry 1988
J R Smith T F Osborne M S Brown J L Goldstein G Gil

Through substitution mutagenesis and gene transfer experiments in cultured cells, we have identified three sequences in the 5' flanking region of the gene for hamster 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase that are required for sterol-mediated regulation of transcription. Point mutations in any one of these sequences largely prevented the increase in transcription that normall...

Journal: :The Journal of biological chemistry 1995
S M Jackson J Ericsson T F Osborne P A Edwards

The transcription of farnesyl diphosphate (FPP) synthase is regulated up to 30-fold by the sterol status of the cell. Point mutations in a 6-base pair ATTGGC sequence in the promoter disrupt both sterol-dependent transcription in vivo as well as binding of the transcription factor NF-Y in vitro. Co-transfection of cells with NF-YA29, a dominant negative form of NF-Y, and various promoter-report...

2017
Yifang Zhang Lili Zhang Hengzi Sun Qingtao Lv Chunping Qiu Xiaoxia Che Zhiming Liu Jie Jiang

The morbidity and mortality associated with endometrial cancer (EC) has increased in recent years. Regarded as a tumor suppressor, forkhead transcription factor 1 (FOXO1) has various biological activities and participates in cell cycle progression, apoptosis and differentiation. Notably, FOXO1 also functions in the regulation of lipogenesis and energy metabolism. Lipogenesis is a feature of can...

Journal: :Journal of lipid research 2006
Saswata Talukdar F Bradley Hillgartner

In birds and mammals, agonists of the liver X receptor (LXR) increase the expression of enzymes that make up the fatty acid synthesis pathway. Here, we investigate the mechanism by which the synthetic LXR agonist, T0-901317, increases the transcription of the acetyl-coenzyme A carboxylase-alpha (ACC alpha) gene in chick embryo hepatocyte cultures. Transfection analyses demonstrate that activati...

Journal: :Journal of lipid research 2013
Kai Cai Marion B Sewer

Diacylglycerol kinase (DGK)θ is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid (PA). We have previously shown that PA is a ligand for the nuclear receptor steroidogenic factor 1 (SF1) and that cAMP-stimulated expression of SF1 target genes requires DGKθ. In this study, we sought to investigate the role of cAMP signaling in regulating DGKθ gene expression. Real time ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Randy Schekman

S tudents of cell biology and physiology are in for a treat with the discoveries, reported in this issue of PNAS by Radhakrishnan et al. (1) and Sun et al. (2), that cholesterol and an enigmatic but potent derivative, 25-OH cholesterol, exert their effect on gene expression by changing the conformation of two membrane protein sensors that guide a transcription factor precursor into the machiner...

Journal: :The Journal of biological chemistry 2010
Yoshinori Takeuchi Naoya Yahagi Yoshihiko Izumida Makiko Nishi Midori Kubota Yuji Teraoka Takashi Yamamoto Takashi Matsuzaka Yoshimi Nakagawa Motohiro Sekiya Yoko Iizuka Ken Ohashi Jun-ichi Osuga Takanari Gotoda Shun Ishibashi Keiji Itaka Kazunori Kataoka Ryozo Nagai Nobuhiro Yamada Takashi Kadowaki Hitoshi Shimano

Sterol regulatory element-binding protein (SREBP)-1 is a key transcription factor for the regulation of lipogenic enzyme genes in the liver. Polyunsaturated fatty acids (PUFA) selectively suppress hepatic SREBP-1, but molecular mechanisms remain largely unknown. To gain insight into this regulation, we established in vivo reporter assays to assess the activities of Srebf1c transcription and pro...

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