نتایج جستجو برای: stiffness matrix
تعداد نتایج: 403797 فیلتر نتایج به سال:
Tumor microvasculature tends to be malformed, more permeable, and more tortuous than vessels in healthy tissue, effects that have been largely attributed to up-regulated VEGF expression. However, tumor tissue tends to stiffen during solid tumor progression, and tissue stiffness is known to alter cell behaviors including proliferation, migration, and cell-cell adhesion, which are all requisite f...
By minimizing the total potential energy function and deploying the virtual work principle, a higher-order stiffness matrix is achieved. This new tangent stiffness matrix is used to solve the frame with geometric nonlinear behavior. Since authors’ formulation takes into account the higher-order terms of the strain vector, the convergence speed of the solution process will increase. In fac...
The biomechanical properties of the extracellular matrix (ECM) play an important role in cell migration, gene expression, and differentiation. Biomechanics measurements of ECM are usually performed on cryotomed tissue sections. However, studies on cell/matrix interplay are impossible to perform due to disruptions in cell viability and tissue architecture from freeze-thaw cycling. We developed a...
Tumor invasion and metastasis are strongly regulated by biophysical interactions between tumor cells and the extracellular matrix (ECM). While the influence of ECM stiffness on cell migration, adhesion, and contractility has been extensively studied in 2D culture, extension of this concept to 3D cultures that more closely resemble tissue has proven challenging, because perturbations that change...
Starting from the definition of a stiffness matrix, the authors present a new formulation of the Cartesian stiffness matrix of parallel mechanisms. The proposed formulation is more general than any other stiffness matrix found in the literature since it can take into account the stiffness of the passive joints, it can consider additional compliances in the joints or in the links and it remains ...
In this paper, the region in which the structural system is situated is divided into four subregions, namely upper, lower, left and right subregions. The stiffness matrix of the entire system is then formed and using the existing direct symmetry and reverse symmetry, the relationships between the entries of the matrix are established. Examples are included to illustrate the steps of the method.
A new method is presented for identifying the local stiffness of a structure from vibration test data. The method is based on a projection of the experimentally measured flexibility matrix onto the strain energy distribution in local elements or regional superelements. Using both a presumed connectivity and a presumed strain energy distribution pattern, the method forms a well-determined linear...
[A] matrix with constants describing the anisotropy of the material [B] strain matrix [BL] linear strain matrix [BNL] nonlinear strain matrix c speed of sound d rate of deformation tensor dp plastic rate of deformation D elastic constitutive tensor [D] matrix of the elastic constitutive tensor [DT] matrix form of the constitutive tensor ds lengths of the vector dx dS lengths of the vector dX dv...
Extracellular matrix stiffness influences biological functions of some tumors. However, it remains unclear how cancer subtypes with different oncogenic mutations respond to matrix stiffness. In addition, the relevance of matrix stiffness to in vivo tumor growth kinetics and drug efficacy remains elusive. Here, we designed 3D hydrogels with physical parameters relevant to hematopoietic tissues a...
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