نتایج جستجو برای: sting
تعداد نتایج: 3148 فیلتر نتایج به سال:
STING (stimulator of interferon genes) has recently been found to play an important role in host defenses against virus and intracellular bacteria via the regulation of type-I IFN signaling and innate immunity. Chronic infection with Helicobacter pylori is identified as the strongest risk factor for gastric cancer. Thus, we aim to explore the function of STING signaling in the development of ga...
An efficient clearance of hepatitis B virus (HBV) requires the coordinated work of both the innate and adaptive immune responses. MITA/STING, an adapter protein of the innate immune signaling pathways, plays a key role in regulating innate and adaptive immune responses to DNA virus infection. Previously, we identified an alternatively spliced isoform of MITA/STING, called MITA-related protein (...
Diamond STING is a new version of the STING suite of programs for a comprehensive analysis of a relationship between protein sequence, structure, function and stability. We have added a number of new functionalities by both providing more structure parameters to the STING Database and by improving/expanding the interface for enhanced data handling. The integration among the STING components has...
Abstract Background and Aims Innate immunity inflammation were recognized as the key factors for progression of acute kidney injury (AKI) induced by lipopolysaccharide (LPS). Stimulator interferon genes (STING) has emerged a critical component innate immune inflammatory responses. This study aimed to explore role STING in LPS-induced tubular AKI. Method 1. The AKI mice models intraperitoneal in...
Sting is an operating system designed to serve as a highly efficient substrate for modern programming languages. Sting includes support for: various models of parallelism and synchronization; lazy, normal, and eager evaluation; automatic storage management; and topology mapping. Sting is different from other operating systems in several respects. The basic concurrency objects in Sting, virtual ...
This study was conducted to test for the effect of three stinging behaviors QTLs (sting-1, sting-2 and sting-3) on the expression of guarding and stinging behavior of individual honey bees, and to determine if results of defensive behavior QTLs found in studies with Africanized honey bees could be extended to other populations of bees. Samples of guards, stingers, foragers and nurse bees were t...
OBJECTIVE To evaluate the protective effects of a jellyfish sting inhibitor formulated in sunscreen lotion vs conventional sunscreen against Chrysaora fuscescens and Chiropsalmus quadrumanus jellyfish. METHODS Twenty-four healthy subjects at 2 research sites were randomly assigned to receive the jellyfish sting inhibitor (Nidaria Technology Ltd, Jordan Valley, Israel) to one forearm and conve...
Abstract With respect to the importance of scorpions sting and identification of manifestations and symptoms in traditional and Iranian medicine, the present study was conducted to review of scorpion sting treatment, prevention and control it on basis traditional medicine and, and discuss about deficit of methods of control and prevention. In this review article, we have searched through i...
Cytosolic DNA-sensing pathways that signal via Stimulator of interferon genes (STING) mediate immunity to pathogens and also promote autoimmune pathology in DNaseII- and DNaseIII-deficient mice. In contrast, we report here that STING potently suppresses inflammation in a model of systemic lupus erythematosus (SLE). Lymphoid hypertrophy, autoantibody production, serum cytokine levels, and other ...
Stimulator of interferon genes (STING) plays an important role in host defense, autoimmune disease, osteoclast differentiation and anti-tumor response. Although many downstream targets have been studied in depth, the regulation of STING gene expression remains largely unknown. Here we demonstrate that transcription factors CREB and c-Myc maintain the transcriptional activity of STING. By 5'-rap...
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